Method for applying a polymer coating to an internal surface of a container

Abstract

A method of cleaning and coating at least one surface of a container for holding a drug or other ingestible non-pharmaceutical product comprising the steps of employing an aqueous cleaning composition together with an aqueous cross-linked acrylic resin comprising a coating. The process enables cleaning and coating techniques to comply with current environmental regulations and workplace safety standards, including controlling the emission of volatile organic compounds (VOCs). In addition, the concentration of extractable organic compounds is reduced to the lowest practical level. The process can also be used for other binders that require low leachable organics and high adhesion to subsequently applied coatings.

Description

technical field [0001] The present invention relates to a method of cleaning and coating at least one surface of a container for holding a medicament, using a unique composition of an aqueous cleaning agent and a special aqueous coating composition, wherein the aqueous cleaning agent is used to increase surface wetting properties and The aqueous coating composition is designed to significantly reduce leachable organics and provide effective drug barrier and low sticking tendency. Background technique [0002] Medications for the treatment of respiratory and nasal conditions are usually administered orally or nasally as aerosol compositions. One widely used method of formulating such aerosol drug compositions involves preparing the drug as a suspension or solution in finely divided powder form in a liquefied gas known as a propellant (propel lant). This suspension is stored in a sealed container (or tank) that can withstand pressure to keep the propellant liquid. The formul...