Method for preparing standard substance for detecting scurf removing agent in cosmetics

A technology of reference material and preparation method, applied in the preparation of test samples, etc., can solve the problems affecting the accuracy of detection, etc., and achieve the effect of accurate detection

Active Publication Date: 2011-01-05
SHANGHAI INOHERB COSMETIC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The detection of anti-dandruff agents in cosmetics is one of the important guarantees for the safety of cosmetics. At present, direct compound detection methods are mostly used. It is quite different from the direct detection of compounds, which will affect the accuracy of detection

Method used

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  • Method for preparing standard substance for detecting scurf removing agent in cosmetics
  • Method for preparing standard substance for detecting scurf removing agent in cosmetics
  • Method for preparing standard substance for detecting scurf removing agent in cosmetics

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] According to formula and preparation process in the table, be mixed with cosmetic emulsion. The anti-dandruff agent Climbazole is formulated into 2.5mg / 100mL propylene glycol solution, then the propylene glycol solution containing the anti-dandruff agent Climbazole is slowly added to the cosmetic emulsion, and the final concentration of Climbazole in the standard substance When the concentration reaches 0.5%, keep the temperature constant at 15-25°C and under the conditions of minimum water evaporation, stir slowly, and pack.

[0036] The purity of Climbazole is ≥99.0%, provided by Shanghai Zhirou Chemical Co., Ltd.

Embodiment 2

[0038] According to formula and preparation process in the table, be mixed with cosmetic emulsion. The anti-dandruff agent pyrrolidone olamine is formulated into 2.5mg / 100mL propylene glycol solution, then the propylene glycol solution containing the anti-dandruff agent pyrrolidone olamine is slowly added to the cosmetic emulsion, and the final concentration of pyrrolidone olamine in the standard substance is When the concentration reaches 0.5%, keep the temperature constant at 15-25°C and under the conditions of minimum water evaporation, stir slowly, and pack.

[0039] Pyrrolidone olamine with a purity of >98.0% was provided by Clariant Chemical Co., Ltd.

Embodiment 3

[0041] According to formula and preparation process in the table, be mixed with cosmetic emulsion. The anti-dandruff agent ketoconazole is formulated into 2.5mg / 100mL propylene glycol solution, then the propylene glycol solution containing the anti-dandruff agent ketoconazole is slowly added to the cosmetic emulsion, and the final concentration of ketoconazole in the standard substance reaches 0.5 %, keep the temperature constant at 15-25°C and slowly stir evenly under the conditions of minimum water evaporation, then pack.

[0042] The purity of ketoconazole is ≥98.5%, provided by Beijing Beililaisi Biochemical Co., Ltd.

[0043] Standard substance of the present invention is used to detect the homogeneity test of anti-dandruff agent in cosmetics:

[0044] Homogeneity is the most basic attribute of standard materials. The project randomly selects n bottles of standard materials developed in accordance with the "Guidelines for Standard Sample Work (5): General Rules for Chemi...

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Abstract

The invention discloses a method for preparing a standard substance for detecting a scurf removing agent in cosmetics. The method comprises a step of mixing propylene glycol solution of the scurf removing agent and cosmetic emulsion to form the standard substance, wherein the cosmetic emulsion comprises the following components in percentage by weight: A phase: 68 to 72 percent of deionized water, 4.5 to 5.5 percent of glycerol, 3 to 3.5 percent of propylene glycol and 0.45 to 0.5 percent of xanthan gum; B phase: 4 to 4.5 percent of stearate, 2 to 4 percent of cetyl alcohol and stearyl alcohol and 10 to 14 percent of No. 26 white oil; and C phase: 1.25 to 1.3 percent of phenoxyethanol and ethylhexylglycerin. The concentration of the scurf removing agent in the standard substance reaches 0.5 percent. The method has the advantages that: the scurf removing agent and the cosmetic emulsion are mixed to form the standard substance for detecting the scurf removing agent such as climbazole, piroctone olamine and ketoconazole; and the standard substance is the same as the cosmetics containing the scurf removing agent in actual use so that the detection of the scurf removing agent in the cosmetics is more accordant with the actual use state and the detection is more accurate.

Description

technical field [0001] The invention relates to the field of cosmetic testing, in particular to a preparation method of a standard substance used for testing anti-dandruff agents in cosmetics. Background technique [0002] The detection of anti-dandruff agents in cosmetics is one of the important guarantees for the safety of cosmetics. At present, direct compound detection methods are mostly used. It is quite different from direct detection of compounds, which will affect the accuracy of detection. Compared with standard compounds, cosmetic standard substances not only have accurate measurement standards, but also have one or more sufficiently uniform and well-determined characteristic values, and have traceability of the value, which is very important for improving cosmetics production, The detection level of cosmetics inspection, the unified measurement value, the evaluation of established cosmetics inspection methods, and the standardization of personnel assessment and m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N1/28G01N1/38
Inventor 陈黎明胡国胜
Owner SHANGHAI INOHERB COSMETIC
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