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Hydroxypropyl-beta-cyclodextrin clathrate compound of cantharidin and cantharis extractive and preparation method thereof

A technology of cantharidin and inclusion compound, applied in the field of cantharidin and cantharidin extract hydroxypropyl-β-cyclodextrin inclusion compound and its preparation, to achieve high inclusion compound formation rate and drug utilization rate, reduce Irritant effects on mucous membranes

Inactive Publication Date: 2011-01-12
INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, cantharidin has strong side effects such as mucosal irritation, which limits its application. Therefore, it is necessary to improve the formulation of cantharidin and cantharidin extracts to improve curative effect, reduce toxic and side effects, and improve the level of clinical treatment.

Method used

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  • Hydroxypropyl-beta-cyclodextrin clathrate compound of cantharidin and cantharis extractive and preparation method thereof
  • Hydroxypropyl-beta-cyclodextrin clathrate compound of cantharidin and cantharis extractive and preparation method thereof
  • Hydroxypropyl-beta-cyclodextrin clathrate compound of cantharidin and cantharis extractive and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0141] Cantharidin 0.020g Hydroxypropyl-β-cyclophane 0.427g

[0142] Weigh cantharidin and hydroxypropyl-β-cyclophane respectively, add 20mL of 70% ethanol, rotate at 100r / min, stir at 30°C for 3h, filter through a 0.22μm microporous membrane, collect the filtrate, and dry at 60°C for 3 hours , that is.

Embodiment 2

[0144] Cantharidin 0.020g Hydroxypropyl-β-cyclophane 0.284g

[0145] Weigh cantharidin and hydroxypropyl-β-cyclophane respectively, add 20mL of 80% ethanol, rotate at 100r / min, stir at a constant temperature of 40°C for 2h, filter through a 0.22μm microporous membrane, collect the filtrate, and dry at 60°C for 4 hours , that is.

Embodiment 3

[0147] Cantharidin 0.020g Hydroxypropyl-β-cyclophane 0.141g

[0148] Weigh cantharidin and hydroxypropyl-β-cyclophane respectively, add 30mL of 60% alcohol, rotate at 100r / min, stir at 50°C for 1h, filter through a 0.22μm microporous membrane, collect the filtrate, and dry at 60°C for 5 hours , that is.

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Abstract

The invention discloses a hydroxypropyl-beta-cyclodextrin clathrate compound of a cantharidin and cantharis extractive and a preparation method thereof. The concrete method comprises the following steps of: precisely weighing cantharidin and hydroxypropyl-beta-cyclodextrin according to the molar ratio; adding 10-30ml of 60-80 percent alcohol; stirring for 1-3 hours at the rotating speed of 90-120r / min and the constant temperature of 30-50 DEG C; filtering through a 0.22mum microporous filter membrane; collecting filter liquor; and drying for 3-5 hours at the temperature of 60 DEG C to obtain the clathrate compound. The hydroxypropyl-beta-cyclodextrin clathrate compound of the cantharidin and cantharis extractive can obviously increase the solubility of drugs and reduces the mucous membrane thrill of the cantharidin and cantharis extractive.

Description

Technical field: [0001] The invention provides an inclusion compound of cantharidin and a cantharidin extract and a preparation method thereof, in particular to a hydroxypropyl-β-cyclodextrin inclusion compound of cantharidin and a cantharidin extract and a preparation method thereof. Background technique [0002] Mylabris is the phylum Arthropoda, the dry body of MyLabris phaLerata PaLLas or MyLabris cichorii Linnaeus, which is an insect of the family Arthropodaceae. It is inferior. According to the records of "Shen Nong's Materia Medica", mylabris can treat diseases such as carbuncle, ulcer, ringworm sore, and has the functions of attacking poisonous erosion and forcing blood to dissipate stagnation. The main chemical components in cantharidin include cantharidin, fat, formic acid, pigment and resin, among which cantharidin, a monoterpene component, is its main component. Cantharidin is a white flaky crystal, sublimated at 120°C, melting point 215-216°C, very slightly so...

Claims

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Application Information

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IPC IPC(8): A61K47/48A61K47/40A61K31/34A61K35/64A61P17/02A61P35/00A61K47/61
Inventor 朱春燕安琳娜
Owner INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
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