Porous biodegradable composite-type bone repairing material and preparation method thereof

Abstract

The invention relates to a porous biodegradable composite-type bone repairing material and a preparation method thereof. The porous biodegradable composite bone repairing material is characterized by comprising a biodegradable bone regeneration repairing material which is prepared from bioceramic particles and a biodegradable macromolecule composite and has a communicated pore structure, wherein the average pore diameter of each pore is 440-810 mum. Through vitro experiments and animal experiments, the bone repairing stent material is shown to have favorable biocompatibility, biodegradability and bone conductibility, can quicken new bone minerals and has the following characteristics that: the material can be prepared according to the size and the shape of a bone defect, the rough surface of the material is easy for adhesion growth of osteoblasts, high porosity of the stent material and the continuity of the pores are easy for cells to be quickly proliferated and dispersed inside the material, and the bone remodeling speed is high and the vivo degradation speed of the material is equivalent to a bone forming speed.

Description

technical field [0001] The invention belongs to a bone regeneration repairing material, in particular to a porous biodegradable composite bone repairing material and a manufacturing method. Background technique [0002] At present, bone regenerative repair materials are mainly used in various medical fields such as orthopedic surgery, plastic surgery and stomatology, for bone tissue regenerative repair treatment of bone defects formed due to various reasons. For example: orthopedic surgery, repairing bone tissue defect areas after resection of bone tumors or osteomyelitis lesions, and bone tissue defect areas after comminuted fractures; plastic surgery and oral orthognathic surgery, filling bone insufficiency during bone shape shaping; oral cavity Implant surgery, in order to meet the needs of implant placement, pre-repair the area of ​​insufficient jaw bone due to various reasons; oral and maxillofacial surgery, repair the palate cleft of patients with cleft palate, etc. H...

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Problems solved by technology

However, the inorganic material for bone tissue repair widely used in clinical practice - tricalcium phosphate bioactive ceramics has good biocompatibility, can directly combine with bone tissue, and has the ability to induce bone regeneration (Kondo N et al., Biomaterials2005, 26 , 5600-08); however, it is difficult to shape and cannot meet the clinical needs of filling complex bone defects, and the hard block material cast out has a slow biodegradation rate, which causes space-occupying obstacles to the continued regeneration of bone tissue. Moreover, body fluid and pre-osteoblasts cannot immerse into the material to differentiate and proliferate, and cannot complete new bone replacement in a short period of time, which prolongs the course of bone repair

Because the implant directly implanted in the material cannot achieve ideal initial stability, and cannot form a biological combination with the material, it needs to wait for the bone-deficient area to be replaced by sufficient new bone before implanting, so a single application of bulk bioactive ceramics prolongs the waiting period for implant placement

[0003] Another organic material for tissue repair in clinical applications—biodegradable polymers such as polymers or copolymers of lactic acid and glycolic acid, have good biocompatibility, strong plasticity, and rapid degradation in vivo; but they degrade in vivo When the mechanical strength decreases, the degradation products produced are acidic, which will reduce the pH of the tissue around the material, which will affect bone regeneration (LiWJ et al., Acta biomaterialia, 2006, 2, 377-85)

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