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Tissue engineering material with bioactive surface structure and preparation method thereof

A surface structure and tissue engineering technology, applied in medical science, prosthesis, etc., can solve the problems of expensive energy consumption, phase separation, and inability to apply insulating polymer matrix in plasma spraying equipment, and achieve stable physical structure and chemical properties. Easy to process and shape, to achieve the effect of bone tissue repair and functional reconstruction

Inactive Publication Date: 2014-05-28
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, plasma spraying equipment is expensive and consumes a lot of energy. The harsh conditions such as high temperature generated during spraying have certain requirements on the substrate material, which is not suitable for polymer substrate materials, and the difference in thermal expansion coefficient between the substrate and the coating is also easy to cause phase separation.
Electrochemical deposition is also a relatively common method for preparing apatite coatings. It has the advantages of mild reaction conditions and can be deposited on surfaces with complex shapes. However, this method is only suitable for conductive materials and cannot be applied to polyamides. Insulating polymer matrix field

Method used

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  • Tissue engineering material with bioactive surface structure and preparation method thereof
  • Tissue engineering material with bioactive surface structure and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0024] Using literature (Yi ZUO, Yubao LI * , Jie WEI and Yonggang YAN, Influence of Ethylene Glycol on the Formation of Calcium Phosphate Nanocrystals, Journal of Materials Science and Technology, Vol.19, No.6, 2003, 628-630) reported wet reaction method, in ethanol Nano-apatite slurry is prepared by reacting calcium hydroamide with phosphoric acid (calcium / phosphorus molar ratio 1.5:1), and then blended with polyamide 66 dissolved in ethanol solution containing 10wt% calcium chloride to prepare The nano-apatite / polyamide 66 composite slurry with a mass ratio of nano-apatite and polyamide 66 of 1:1 and a viscosity of 5000 mPa·s. The injection-molded polyamide 66 film with a thickness of about 2mm was immersed in the composite slurry at 60°C, stirred at a low speed for 6 hours, then taken out, and dried at room temperature. The scanning electron microscope showed that the composite surface layer of nano-apatite and polyamide was prepared It is a tightly integrated structure w...

Embodiment 2

[0026] According to literature (Li Yubao, K.de Groot, J.de Wijn, C.P.A.T.Klein and S.v.d.Meer, Morphology and Composition of Nanograde Calcium Phosphate Needle-Like Crystals Formed by Simple Hydrothermal Treatment, J.Mater.Sci: Mater.in Med. , 5(1994): 326-331) report, with water as the reaction medium, the nano-apatite slurry prepared by calcium chloride and ammonium dihydrogen phosphate (calcium / phosphorus molar ratio 1.67: 1), Disperse with methanol after centrifugal dehydration, and then blend and compound with polyamide 6 solution dissolved in methanol solution containing 20wt% calcium chloride to obtain nano-apatite and polyamide 66 with a mass ratio of 3:2 and a viscosity of 2000mPa. s corresponding nanoapatite / polyamide 6 composite slurry. The injection-molded polyamide 6 cylinder with a diameter of about 3mm was immersed in the composite slurry at 80°C, stirred at a low speed for 8 hours, then taken out, and vacuum-dried at 60°C. The prepared nano-apatite and polyamid...

Embodiment 3

[0028] According to literature (Y.Y.Wang, Y.B.Li * , Y.Zuo, H.N.Wang, L.Cheng, G.Zhou, The influence of preparation condition on nano-hydroxyapatite prepared in different solvent, Materials Science Forum, 2007, Vol.544-545:897-900) reported method, Nano-apatite slurry was synthesized by the reaction of calcium nitrate and sodium dihydrogen phosphate (calcium / phosphorus molar ratio 1.60:1) in an ethanol solvent, and then mixed with polyamide 1010 dissolved in a glycerol solution of 30 wt% calcium nitrate Mix and compound to obtain a nanoapatite / polyamide 1010 composite slurry with a mass ratio of nanoapatite and polyamide 1010 of 2:1 and a viscosity of 8000 mPa·s. The molded size is about 5×5×10mm 3 The polyamide 1010 solid block was immersed in the composite slurry at 40°C, stirred and reacted at a low speed for 5 hours, then taken out, and dried in a vacuum oven at 120°C. The prepared composite surface layer and the base material were a tightly integrated structure without p...

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Abstract

The invention relates to a tissue engineering material with a bioactive surface structure and a preparation method thereof. The tissue engineering material is prepared by using a polyamide material as a matrix and covering an active surface structure containing nano apatite porous surface with thickness of 50-500mu m on the surface, wherein the pore diameter of pores on the surface is 0.5-50mu m. The tissue engineering material is importantly characterized in that the active surface structure rich in the apatite is prepared on the surface of an insulative macromolecule matrix material, the content of the apatite is gradually increased from inside to outside in the surface structure, the physical structure and the chemical properties are stable, and the surface structure is tightly combined with the matrix into an integral structure without phase separation. The porous surface structure rich in the nano apatite has the advantages of simple preparation process and easy control, can be used for preparing the surface bioactive surface layer of the matrix formed by various polyamide materials to meet different clinical demands, and is hopeful to being widely applied to the bone tissue repair.

Description

technical field [0001] The invention relates to a tissue engineering material for medical treatment, in particular to the tissue engineering material covered with a nano-apatite porous active surface structure on the surface of a polyamide material matrix. Background technique [0002] Polyamide is an important class of engineering and medical plastics. It has good processing properties and can produce various forms of products through different processing methods. For example, polyamide fibers can be prepared by electrospinning, and polyamide film materials can be prepared by blow molding. , Prepare solid or porous structure materials by injection molding and compression molding to meet various needs in engineering and medicine. At the same time, due to its high strength and good biocompatibility, polyamide has been used clinically as sutures and artificial skin. [0003] The molecular structure of polyamide contains a large number of polar amide groups (-CO-NH-), and hydr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/40A61L27/18A61L27/12C08J9/28C08J7/12C08L77/00
Inventor 李玉宝黄棣左奕李吉东
Owner SICHUAN UNIV