Lamiophlomis rotata extract, medicine composition containing same and quality control method thereof
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A unique flavor and extract technology, applied in the field of medicine, can solve the problems of reporting index components without quality control, and achieve the effect of clear drug effect, strong controllability and stable drug effect
Active Publication Date: 2011-03-16
HENGKANG MEDICAL GROUP CO LTD
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8-o-acetyl shanzhiside methyl ester is 4 iridoid glycosides separated from the n-butanol extract of the root of the unique herb (see: Yi Jinhai et al. Research, Acta Pharmaceutica Sinica, 1997, 32(5): 357-360), at present, there is no report that the two compounds are simultaneously used as index components for quality control
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Embodiment 1
[0029] The preparation of embodiment 1 pharmaceutical material extract of the present invention
[0030] Take 1000g of unique herb, crush it, add water and decoct 3 times, the first time is 2 hours, the second and third times are 1 hour respectively, and the amount of water added each time is 8 times, the decoction is combined, filtered, and the filtrate is concentrated to relative density 1.30 (85 ℃) clear paste, dry below 80 ℃, pulverize, and the paste rate is 15-25%.
Embodiment 2
[0031] The preparation of embodiment 2 pharmaceutical material extracts of the present invention
[0032] Take 1000g of unique medicinal material, crush it, add 20 times of water and soak for 24 hours, the water temperature is 85°C, filter, the filtrate is concentrated into a clear paste with a relative density of 1.30 (85°C), dried, crushed, and the paste yield is 12-18%
Embodiment 3
[0033] The preparation of embodiment 3 pharmaceutical material extracts of the present invention
[0034] Take 1000g of unique medicinal material, grind it, add water and pressurize extraction in a pressure extraction tank for 3 times, the first time is 2 hours, the second and third time are 1 hour respectively, the amount of water added each time is 8 times, the temperature is 120 ° C, combined The extract is filtered, concentrated, dried and pulverized to obtain a paste rate of 18-25%.
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Abstract
The invention provides a lamiophlomis rotata extract which comprises Shanzhiside methylester and 8-O-Acetylshanzhiside methyl ester, wherein in per gram of the extract, the total weight of the Shanzhiside methylester and the 8-O-Acetylshanzhiside methyl ester is no less than 5mg. The invention also provides a method for controlling the quality of a lamiophlomis rotata medicinal material or the lamiophlomis rotata extract, or a medicine composition containing the lamiophlomis rotata extract, and in the method, the Shanzhiside methylester and the 8-O-Acetylshanzhiside methyl ester are taken as marker components for carrying out quality test. The extract has stable drug effect and strong controllability; since the Shanzhiside methylester and the 8-O-Acetylshanzhiside methyl ester are taken as the marker components for controlling the quality of the extract, the drug effect is definite, and the controllability is strong; the quality control method is accurate, reliable, stable and controllable; and the quality of lamiophlomis rotate medicines can be effectively monitored by utilizing the quality control method to measure the content of the lamiophlomis rotata medicinal material or thecontent of the Shanzhiside methylester in preparations.
Description
technical field [0001] The present invention relates to a unique herb extract, a pharmaceutical composition containing the extract and a quality control method, which belong to the field of medicine. Background technique [0002] Duyiwei is a traditional Tibetan medicinal material. It is the root, rhizome and whole plant of Lamio-phlomis rotata (Benth.) Kudo, a plant of the Labiatae family. It grows on plateaus or mountains above 3000m above sea level. Duyi is mildly cold in nature, bitter in taste, and slightly poisonous; effects: promoting blood circulation, promoting blood stasis, reducing swelling, and relieving pain; it is mainly used to treat tendons and bones due to bruises, lumbar contusion, and yellow water in joints. Its chemical components include: flavonoids, iridoids, phenylethanol glycosides, etc. The reported pharmacological activities include analgesic effect, hemostatic effect, anti-inflammatory effect, anti-tumor effect, and the effect on bone marrow myeloi...
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