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Application of resveratrol in preparing medicament for preventing and treating radiation induced depigmentation skin disease

A technology induced by resveratrol and radiation, applied in the field of development, can solve the problems of low cure rate, easy to delay progress, and great physical and mental pressure caused by patients

Inactive Publication Date: 2011-04-06
INST OF RADIATION MEDICINE CHINESE ACADEMY OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Vitiligo is a common depigmentation skin disease. The clinical manifestation is localized white spots on the skin. Once the onset occurs, the cure rate is low and the progress is easy to be delayed, causing great physical and mental pressure to the patient.

Method used

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  • Application of resveratrol in preparing medicament for preventing and treating radiation induced depigmentation skin disease
  • Application of resveratrol in preparing medicament for preventing and treating radiation induced depigmentation skin disease
  • Application of resveratrol in preparing medicament for preventing and treating radiation induced depigmentation skin disease

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Purpose

[0039] Observe the therapeutic effect of the application of resveratrol on radiation-induced hair decolorization in IRM-2 mice.

[0040] Experimental Materials

[0041] 1. Laboratory animal IRM-2 mice, from the Institute of Radiation Medicine, Chinese Academy of Medical Sciences, certificate number: SCXK (jin): 2005-0001

[0042] 2. Reagent resveratrol was provided by the Institute of Materia Medica, Chinese Academy of Medical Sciences: purchased from Zhejiang Yixin Pharmaceutical Co., Ltd., with a content of 98%, batch number 20060718, and diluted with Tween 80 before use.

[0043] 3. Experimental equipment 137 Cs gamma radiation source: Canadian Atomic Energy Co., Ltd., USD type, Autocell 140. Microscope OLYMPUS BX51, automatic blood analyzer sysmex poch-100i.

[0044] experimental method

[0045] 4. Experimental grouping and irradiation

[0046] In this experiment, mice were divided into normal group, irradiation group, and irradiation+resveratrol group; each group had...

Embodiment 2

[0073] Resveratrol 20g, microcrystalline cellulose 80g, lactose 283g, croscarmellose sodium 24g, appropriate amount of 3% hydroxypropylcellulose aqueous solution, 4g magnesium stearate are conventionally made into 1000 tablets.

Embodiment 3

[0075] Preparation of capsules: 60g resveratrol, 200g dextrin, 370g lactose, granulated with 70% ethanol, dried, and encapsulated to make 1000 capsules.

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Abstract

The invention discloses application of resveratrol in preparing a medicament for preventing and treating radiation induced depigmentation skin disease. A path for treating occurrence and development of ionizing radiation induced leucoderma is established by treating a radiation induced IRM-2 mouse leucoderma model with resveratrol. Mice irradiated by 6Gy after 30 days orally take the medicament for 15 days, and then the result shows that the depigmentation inhibiting rate of the medicament administration group reaches 40% compared with the control group, so the medicament has remarkable effect. Pathological detection results show that hair follicles of the pathological change part of the mice of the resveratrol administration group are distributed more densely, and the distribution of melanin is obviously wider than that of an irradiation group and a normal group. The immune indexes of the mice of the resveratrol administration group, such as peripheral blood leukocyte number, femoral nucleated cell number, CFU-S (colony forming unit-spleen), CFU-GM (colony forming unit-granulocyte and monocyte) and the like, are slightly higher than those of the irradiation group, so the resveratrol has certain protection effect on hematopoiesis and immunologic function of the irradiated mice. The results show that the resveratrol has positive prevention and treatment effect on the occurrence and development of the radiation induced mice leucoderma.

Description

Technical field [0001] The invention belongs to the technical field of application of Chinese medicinal materials, and relates to the application of resveratrol in the prevention and treatment of radiation-induced depigmentation skin diseases. More specifically, the application of resveratrol in the prevention and treatment of radiation-induced depigmentation of mouse hair Applications. Background technique [0002] Resveratrol (resveratrol, RES) is a natural polyphenol with strong biological activity. It is a chemopreventive agent for tumors. It is also a chemical for reducing platelet aggregation, preventing and treating atherosclerosis and cardiovascular and cerebrovascular diseases. Preventive agent. Resveratrol is widely found in seed plants. It is abundant in traditional Chinese medicine Veratrum and Polygonum cuspidatum. Its chemical name is 3,4,'5-trihydroxy-trans-stilbene (3,4,'5-trihydroxysitlbene). ), has two structures, cis and trans, and trans has biological activi...

Claims

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Application Information

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IPC IPC(8): A61K31/05A61P17/00
Inventor 吴红英王月英孟爱民侯琦李德冠张恒王小春路璐王彦杜利清常建辉翟志斌
Owner INST OF RADIATION MEDICINE CHINESE ACADEMY OF MEDICAL SCI
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