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Qiqing Baidu effervescent granule and preparation method thereof

A technology of effervescent granules and diluents, which is applied in the direction of medical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc. Solve problems such as large paste ratio and slow disintegration time, achieve good clarity, reduce the amount of excipients, and fast effervescence

Active Publication Date: 2012-06-06
HENAN HUITONG TIANXIA BIO ENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Due to the large proportion of medicinal extracts in Chinese medicine effervescent granules, it is difficult to select the type and proportion of medicinal extracts and pharmaceutical excipients. Most of the existing Chinese medicine effervescent granules have slow disintegration time, poor stability, and poor taste At the same time, due to the acid-base reaction of the disintegrant itself and the influence of environmental moisture during the storage process, the effervescent granules are prone to produce gas during storage, which makes the prepared product appear swollen bags, gas, etc. bad situation

Method used

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  • Qiqing Baidu effervescent granule and preparation method thereof
  • Qiqing Baidu effervescent granule and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0057] 1. Qiqingbaidu effervescent granule, which is prepared according to the following raw materials and auxiliary materials in the weight ratio:

[0058] The raw materials are: 100g of Scutellaria baicalensis, 100g of Polygonum cuspidatum, 80g of Pulsatilla chinensis, 80g of Sophora flavescens, 100g of Radix Isatidis, 60g of Mianma Guanzhong, 40g of Daqingye;

[0059] The auxiliary materials are: sodium bicarbonate 80g, fumaric acid 67g, diluent: glucose 367g, dextrin 33g, flavoring agent: stevia 13g.

[0060] 2. The preparation method of Qiqingbaidu effervescent granules is carried out according to the following steps:

[0061] (1) Weigh the prescribed amount of Scutellaria baicalensis, Polygonum cuspidatum, Pulsatilla radix, Sophora flavescens, Isatidis root, Mianma Guanzhong, and Folium basilicum, and boil it in water 8 times the weight of the medicinal materials, decoct twice, 2 hours each time, combine Decoction, filter, combine the filtrates, let stand, take the supe...

Embodiment 2

[0066] 1. Qiqingbaidu effervescent granule, which is prepared according to the following raw materials and auxiliary materials in the weight ratio:

[0067] The raw materials are: 100g of Scutellaria baicalensis, 100g of Polygonum cuspidatum, 80g of Pulsatilla chinensis, 80g of Sophora flavescens, 100g of Radix Isatidis, 60g of Mianma Guanzhong, and 40g of Daqingye.

[0068] The auxiliary materials are: sodium bicarbonate 72g, fumaric acid 60g, diluent: mannitol 387g, flavoring agent: aspartame 11g.

[0069] 2. The preparation method of Qiqingbaidu effervescent granules: repeat the preparation method in Example 1 to obtain the Qiqingbaidu effervescent granules of the present invention.

Embodiment 3

[0071] 1. Qiqingbaidu effervescent granule, which is prepared according to the following raw materials and auxiliary materials in the weight ratio:

[0072] The raw materials are: 100g of Scutellaria baicalensis, 100g of Polygonum cuspidatum, 80g of Pulsatilla chinensis, 80g of Sophora flavescens, 100g of Radix Isatidis, 60g of Mianma Guanzhong, and 40g of Daqingye.

[0073] Excipients: 76g sodium bicarbonate, 62g fumaric acid, diluent: 200g soluble starch, 100g microcrystalline cellulose, 90g dextrin, flavoring agent: 4g sodium saccharin, 4g calcium saccharin, 4g sodium cyclamate .

[0074] 2. The preparation method of Qiqingbaidu effervescent granules: repeat the preparation method in Example 1 to obtain the Qiqingbaidu effervescent granules of the present invention.

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Abstract

The invention relates to a Qiqing Baidu effervescent granule, belonging to the pharmaceutical field of traditional Chinese medicines. The Qiqing Baidu effervescent granule is prepared from the following raw materials and auxiliary materials in part by weight: raw materials: 100 parts of baical skullcap root, 100 parts of giant knotweed rhizome, 80 parts of pulsatilla chinensis, 80 parts of lightyellow sophora root, 100 parts of isatis root, 60 parts of male fern rhizome and 40 parts of indigowoad leaves; and auxiliary materials: 72-88 parts of sodium bicarbonate, 60-74 parts of fumaric acid, 387-417 parts of thinning agents and 11-15 parts of flavoring agents. The effervescent granule is prepared by utilizing a method for separately granulating with acid-alkali. In the invention, the Qiqing Baidu effervescent granule is prepared by taking the sodium bicarbonate as an alkaline agent and fumaric acid as an acidic agent and adding other auxiliary materials; the use level of the auxiliarymaterials can be reduced; and the effervescent granule has the advantages of simple preparation process, high effervescent speed, favorable effervescent effect, dissolubility and liquid medicine clarity after being effervesced, is easily formed and does not absorb moisture easily.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and in particular relates to a Qiqingbaidu effervescent granule and a preparation method thereof. Background technique [0002] Qiqingbaidu granule is prepared by extracting Qiqingbaidu extract from seven traditional Chinese medicines such as Scutellaria baicalensis, Polygonum cuspidatum, Pulsatilla, Sophora flavescens, Banlangen, Mianma Guanzhong, and Daqingye, and then mixed with sugar and dextrin in a certain proportion. The finished granules have the functions of clearing heat and detoxifying, drying dampness and stopping diarrhea, and are mainly used clinically for the treatment of damp-heat diarrhea and chicken pullorum. Because of its exact curative effect and good reputation, it is included in the 2005 edition of Veterinary Pharmacopoeia of the People's Republic of China, Part 2 P 401 . However, when Qiqingbaidu granule is used clinically, it dissolves slowly and has...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K36/71A61K47/12A61K47/02A61P1/12A61P31/04
Inventor 张要齐李怀生孙雪峰朱静静
Owner HENAN HUITONG TIANXIA BIO ENG
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