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Integrated microfluidic chip interface, interface mould, and interface manufacturing and using methods

A microfluidic chip, chip technology, applied in microstructure technology, microstructure devices, manufacturing microstructure devices, etc., can solve the problems of microchannel blockage, adhesive infiltration, etc., achieve good sealing effect, and achieve the effect of batch processing

Active Publication Date: 2011-04-27
NORTHWESTERN POLYTECHNICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage of this adhesive-based capillary-microfluidic chip interface is that the adhesive easily penetrates into the microfluidic chip through the gap between the capillary and the rubber stopper or the rubber stopper and the microfluidic chip, causing the microchannel to be blocked.

Method used

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  • Integrated microfluidic chip interface, interface mould, and interface manufacturing and using methods
  • Integrated microfluidic chip interface, interface mould, and interface manufacturing and using methods
  • Integrated microfluidic chip interface, interface mould, and interface manufacturing and using methods

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] refer to figure 2 , image 3 , this embodiment provides a two-port integrated microfluidic chip interface made of PDMS, including a horizontal substrate 1 sealed on the microfluidic chip 4 and two bosses 2 on the horizontal substrate 1; There is a connecting pipe 3 inside the boss 2, and the connecting pipe 3 connects the microchannel on the microfluidic chip 4 with the outside world. Among them, the dimensions of the horizontal base 1 are: length 40mm, width 20mm, thickness 2mm; boss 2 is a round tube with an outer diameter of 5 mm and a height of 6 mm; the inner diameter of the connecting pipe 3 is 2 mm.

[0043] refer to Figure 4 , the integrated microfluidic chip interface mold material used in the present embodiment is PMMA, including the bottom plate 17 with the male mold microcolumn connecting the pipeline, the female mold orifice plate 9 of the boss and the horizontal base cofferdam 6; There is the base plate 17 of connecting pipe male mold microcolumn to b...

specific Embodiment 2

[0053] refer to Figure 7 , Figure 8 , this embodiment provides a four-port integrated microfluidic chip interface made of PDMS, including a horizontal substrate 1 sealed on the microfluidic chip 4 and four bosses 2 on the horizontal substrate 1; There is a connecting pipe 3 inside the boss 2, and the connecting pipe 3 connects the microchannel on the microfluidic chip 4 with the outside world. Among them, the size of the horizontal base 1 is: length 90mm, width 40mm, thickness 3mm; boss 2 is a round tube with an outer diameter of 6 mm and a height of 8 mm; the inner diameter of the connecting pipe 3 is 3 mm.

[0054] refer to Figure 9 , the integrated microfluidic chip interface mold material used in this embodiment is PC, which successively includes a bottom plate 13, a male die microcolumn fixed orifice plate 12 for connecting pipes, a female die orifice plate 9 for a boss, and a horizontal base cofferdam 6; The connecting pipe male mold microcolumn fixed orifice 12 is...

specific Embodiment 3

[0064] refer to Figure 12 , Figure 13 , this embodiment provides a multi-port integrated microfluidic chip interface made of PDMS, including a horizontal substrate 1 sealed on the microfluidic chip 4 and 19 bosses 2 located on the horizontal substrate 1; There is a connecting pipe 3 inside the boss 2, and the connecting pipe 3 connects the microchannel on the microfluidic chip 4 with the outside world. Wherein, the horizontal substrate 1 is a disk with a diameter of 100 mm and a thickness of 3 mm; the boss 2 is a circular tube with an outer diameter of 6 mm and a height of 6 mm; the inner diameter of the connecting pipe 3 is 4 mm.

[0065] refer to Figure 14 , the material of the integrated microfluidic chip interface mold used in this embodiment is nickel, which successively includes a bottom plate 13, a fixed orifice plate 12 for connecting pipe male mold microcolumns, a boss female mold orifice plate 9 and a horizontal base cofferdam 6; The connecting pipe male mold m...

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Abstract

The invention discloses an integrated microfluidic chip interface, which belongs to the field of microfluidic chips. The interface comprises a horizontal substrate 1 and a plurality of lug bosses 2, wherein the horizontal substrate 1 is arranged above the microfluidic chip 4 in a sealing connection way; the plurality of lug bosses 2 are positioned on the horizontal substrate 1; and connecting pipelines 3 are arranged in the lug bosses 2, and communicate microchannels on the microfluidic chip 4 with the outside. In addition, the invention also discloses a method for manufacturing the interfacebased on a mould and an interface using method. The integrated microfluidic chip interface provided by the invention can realize connection between an external microscopic system and a microfluidic chip system without using an adhesive, achieves a good sealing effect and does not cause the blockage of the microchannels. In the method for manufacturing the interface, the batch machining of the integrated microfluidic chip interfaces can be realized by the interface mould.

Description

[0001] 1. Fields: [0002] The invention relates to an integrated microfluidic chip interface, an interface mold and methods for making and using the interface, and belongs to the field of microfluidic chips. 2. Background technology: [0003] Microfluidic chip, also known as microfluidic chip laboratory, refers to a chemical or biological laboratory built on a chip of a few square centimeters. It integrates the basic operation units involved in the fields of chemistry and biology such as sample preparation, reaction, separation, detection, cell culture, sorting, lysis, etc. into a small chip, and forms a network of microchannels to control fluid flow. Throughout the system, it is used to realize various functions of conventional chemical or biological laboratories. [0004] The scale of the channel or member in the microfluidic chip is tens to hundreds of microns, and the volume of the carrying fluid is 10 -9 ~10 -18 L. The microscale of the microfluidic chip determines t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N35/00B29C45/26B81C1/00
Inventor 苑伟政张峰常洪龙郝思聪丁继亮谢建兵陈方璐
Owner NORTHWESTERN POLYTECHNICAL UNIV
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