Method for comprehensively extracting synephrine and hesperidine from immature bitter orange raw material

A technology for comprehensive extraction and hesperidin, applied in the field of traditional Chinese medicine chemistry, to achieve the effects of reducing production costs, shortening the process, and optimizing extraction

Active Publication Date: 2011-05-11
三原润禾生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] The present invention proposes a method for comprehensively extracting synephrine and hesperidin from citrus aurantium raw materials to overcome the waste of resources caused by the inability to comprehensively develop the two products in the prior art, optimize the extraction steps, reduce production costs, and improve Operability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Get 100kg of citrus aurantium raw material soaked and pulverized, extract with 90% methanol at a concentration of 3 times the mass of the raw material, which contains 1% sodium hydroxide by solvent mass, extract three times at an extraction temperature of 50°C, and combine the above three extracts , concentrate to get the extract, and the specific gravity of the heat-measured extract is 1.07.

[0043] Let the above-mentioned extract cool, filter to obtain a supernatant, add activated carbon with 5% raw material mass to the solution for decolorization for 1 hour, and decolorize at a temperature of 50° C., and filter while hot to obtain a solution.

[0044]The filtered supernatant was adjusted to pH=4 with hydrochloric acid, placed at room temperature for 8 hours, centrifuged, the precipitate was washed with purified water until the effluent was detected to be neutral, and dried in a vacuum drying oven to obtain a light yellow powder. The hesperidin product has a yield of...

Embodiment 2

[0047] Get 100kg of citrus citrus raw material soaked and pulverized, extract with 90% acetone at a concentration of 8 times the mass of raw material, which contains 3% sodium carbonate of solvent quality, extract three times at an extraction temperature of 75°C, and combine the above three extracts, Concentrate to obtain the extract, and the specific gravity of the extract by heat measurement is 1.10.

[0048] Let the above extract cool, filter to obtain a supernatant, add 7% active magnesium oxide to the solution for decolorization for 0.5 hour, the decolorization temperature is 50° C., and filter while hot to obtain a solution.

[0049] The filtered supernatant was adjusted to pH=3 with acetic acid, placed at room temperature for 8 hours, centrifuged, the precipitate was washed with purified water until the effluent was detected as neutral, and dried in a vacuum oven to obtain a light yellow powder. It is a hesperidin product with a yield of 24.2% and a content of 93.4%.

...

Embodiment 3

[0052] Get 100kg of citrus aurantium raw material soaked and pulverized, extract with 90% ethanol with a concentration of 5 times the mass of the raw material, which contains 2% sodium hydroxide by solvent mass, extract three times at an extraction temperature of 75°C, and combine the above three extracts , concentrate to get the extract, and the specific gravity of the heat-measured extract is 1.05.

[0053] Let the above-mentioned extract cool, filter to obtain a supernatant, add 10% active clay of raw material mass to the solution for decolorization for 0.5 hour, the decolorization temperature is 50° C., and filter while hot to obtain a solution.

[0054] The filtered supernatant was adjusted to pH=5 with a 20% citric acid solution, placed at room temperature for 8 hours, centrifuged, the precipitate was washed with purified water until the effluent was detected as neutral, and dried in a vacuum oven to obtain The light yellow powdery substance is a hesperidin product, the ...

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PUM

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Abstract

The invention discloses a method for comprehensively extracting synephrine and hesperidine from an immature bitter orange raw material, which overcomes the disadvantage of resource waste because two products cannot be comprehensively developed in the prior art, optimizes extraction steps, reduces production cost and improves operability. The method comprises the following steps of: after crushingthe raw material, extracting by adopting an alkaline organic solvent; combining the extract; concentrating to the specific gravity of 1.05; filtering, decoloring the filtrate; adjusting the filtrate to be neutral; filtering to obtain a hesperidine product, wherein the yield is 25 percent and the content is 95 percent; adjusting mother liquor obtained by filtering to be strongly alkaline; extracting by adopting a mixed organic solvent; and concentrating to a certain volume and adding a low-polarity solvent for crystallizing, wherein the product yield is 1.2 percent and the synephrine content is 98 percent. The method makes full use of the immature bitter orange raw material, designs a process for producing the two products, namely the synephrine and the hesperidine, at the same time, greatly reduces the production cost, optimizes an overall extraction process, shortens a process flow and saves the production cost.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine chemistry and relates to a method for extracting synephrine and hesperidin, in particular to a method for comprehensively extracting synephrine and hesperidin from citrus aurantium raw materials. Background technique [0002] Citrus aurantium is the dry young fruit of Rutaceae plant sour orange and its variants or sweet orange. The main chemical components are: volatile oil, flavonoids and alkaloids. Among them, synephrine is one of the alkaloids in Citrus aurantium, which has the functions of constricting blood vessels, raising blood pressure and strong expansion of trachea and bronchi. It is used for anti-shock and anti-heart failure, and has weight loss effect. It is a natural stimulant . The main flavonoid component in Citrus aurantium is hesperidin. Its medicinal value is to maintain the normal permeability of blood vessels, increase the resistance of capillaries, inhib...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/07C07H1/08C07C215/60C07C213/10
Inventor 王晓莹肖红吴卫国金富林周建兴
Owner 三原润禾生物科技有限公司
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