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Scalable cell culture bioreactor and cell culture process

A bioreactor, scaling technology, applied in biochemical equipment and methods, methods of supporting/immobilizing microorganisms, methods of sterilization, etc., can solve problems such as limiting the scale of HFR design

Inactive Publication Date: 2011-05-11
QUORUS BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, axial gradients and inhomogeneities within the hollow fiber bundle are still observed and limit the scale of HFR designs

Method used

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  • Scalable cell culture bioreactor and cell culture process
  • Scalable cell culture bioreactor and cell culture process
  • Scalable cell culture bioreactor and cell culture process

Examples

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Embodiment Construction

[0053] In this design, the principle of modular augmentation and processing flexibility is incorporated into the 2-D and 3-D designs of capillary network membranes. Scalable membrane bioreactor equipment ( figure 2 and 3 ) includes 2 top plates (1) and at least 1 box body (5) fixed between the 2 top plates, effectively defining the extracapillary space (ECS), and separating it from the inner capillary space (ICS) located in the hollow fiber membrane )differentiate. figure 2 The complete cell culture module is shown showing 2 top plates (1 ) holding eg 7 individual cassettes (5). The upper and / or lower top panels may include a central transparent viewing panel (2) which allows viewing of the interior of the module during operation. Each top plate may also include at least 1 ECS hole (3, 4), which functions as an inlet / outlet to the ECS; and at least 1 fitting or hole, which allows passage of, for example, a pH fitting (29) or a DO probe (30) Insert the probe or sensor int...

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Abstract

The present invention relates to a scaleable bioreactor comprising at least one cassette comprising a manifold and an arrangement of hollow fibre membranes; an upper headplate; and a lower headplate, wherein the cassette(s) are modular components adapted to co-operate with each other and the headplates to define an internal extracapillary culture space (ECS) and wherein the arrangement of hollow fibre membranes includes a discrete inlet and outlet. The invention further relates to a kit for such a bioreactor, a cassette for ue in such a bioreactor and a process for exploiting the metabolism of cells and / or microorganisms, the process including the step of utilising a bioreactor according to the invention.

Description

【Technical field】 [0001] The present invention relates to scalable capillary (hollow fiber) membrane bioreactors and uses thereof for the cultivation and maintenance of cells and / or microorganisms to exploit the metabolism of these cells for the production of biological products or Biotransformation. 【Background technique】 [0002] Capillary membrane or hollow fiber reactors (HFRs) have been widely used in upstream and downstream filtration and purification processes; in wastewater treatment as bioreactors with immobilized microorganisms or enzymes; and as cell or tissue culture systems. [0003] Most cell culture HFR designs use axial flow, where separate fluid streams pass across the membrane surface on either side of the membrane (Chresand et al, 1987). These modules are increased by increasing the number of membranes contained in the hollow fiber bundles within the cylindrical manifold, thereby increasing the active membrane surface area. Substances or nutrients are ex...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M1/12
CPCC12M23/40C12M23/44C12M25/10C12M29/16
Inventor W·爱德华兹S·J·弗拉瑟
Owner QUORUS BIOTECH
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