A medical analysis system

An analysis system, medical technology, applied in the field of medical analysis system, can solve problems such as inconsistent clinical significance

Inactive Publication Date: 2011-06-01
KONINKLIJKE PHILIPS ELECTRONICS NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] However, further refinement of molecular classification can lead to inconsistent clinical significance

Method used

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  • A medical analysis system
  • A medical analysis system
  • A medical analysis system

Examples

Experimental program
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Effect test

Embodiment 1

[0241] The application starts with an analysis screen with the default patient downloaded ( Figure 4 ). From this screen the user can download the patient's information and start performing different kinds of analyzes provided in the Genome Design and Analysis Toolbox (GDAT). The first modality shown is histology, where a summary of the histopathological analysis performed on a patient sample can be seen.

[0242] Download patient information from database

[0243] Summary patient (sample) information from the database is shown and the application allows selection (highlighting) of patients for further analysis ( Figure 5 ).

Embodiment 2

[0245] Histopathological modality

[0246] A summary of the histopathological analysis for a given patient is shown in this screen, including estrogen receptor, progesterone (Progesteror) receptor, Her2 overexpression by FISH, and immunohistochemical status ( Figure 6 ).

Embodiment 3

[0248] CGH mode

[0249] A summary of comparative genomic hybridization (CGH) data associated with the sample, such as gene amplifications, deletion numbers, etc., and a sample's Firestorm index from ROMA data (representational oligonucleotide microarray analysis). see Figure 7 .

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Abstract

The present invention relates to effective diagnosis of patients and assisting clinicians in treatment planning. In particular, the invention provides a medical analysis system that enables refinement of molecular classification. The system provides a molecular profiling solution that will allow improved diagnosis, prognosis, response prediction to provide the right chemotherapy, and follow-up to monitor for cancer recurrence.

Description

technical field [0001] The invention relates to a medical analysis system. In particular, the invention relates to a corresponding method and a corresponding computer program product. Background technique [0002] Breast cancer is a complex genetic disease driven by the accumulation of multiple molecular alterations. Recent molecular advances in high-throughput genomics, transcriptomics, and epigenomic technologies have enabled focusing on the molecular complexity of breast cancer and helping to guide cancer prediction and treatment prediction. [0003] demonstrated that breast cancers can be classified into distinct groups based on their gene expression profiles. The estrogen receptor positive (ER+) group is characterized by higher expression of a set of genes typically expressed by breast luminal epithelial cells ('luminal' cancers). The ER branch includes three tumor subtypes: 1) overexpressing ERBB2 (HER2); 2) expressing genes characteristic of breast basal cells (bas...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06F19/00G16H50/20G16H70/20
CPCG06F19/3443G06Q50/22G16H50/70G16H50/20G16H70/20G16H50/50
Inventor A·J·贾尼夫斯基N·迪米特罗瓦S·卡马拉卡兰Y·H·阿尔萨法迪N·巴纳吉A·I·D·布库尔J·J·A·范利尤文V·V·瓦拉丹
Owner KONINKLIJKE PHILIPS ELECTRONICS NV
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