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Cream preparation for preventing and curing mammary gland hyperplasia and preparation method thereof

A technology of mammary gland hyperplasia and cream, which is applied in the field of traditional Chinese medicine, can solve problems such as side effects, inability to remove production factors, aggravate endocrine disorders, etc., achieve quick results, prevent breast cancer, and control mammary gland hyperplasia

Active Publication Date: 2011-06-08
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the Western medicine treatment of hyperplasia of mammary glands is still mainly based on oral hormones and surgery, but surgery can only remove local lesions and cannot relieve the formation factors, and other parts can still occur or continue to grow; although hormone replacement therapy can relieve clinical symptoms in a short time , but it cannot fundamentally adjust the endocrine function, and long-term use will easily aggravate endocrine disorders, and cause serious side effects and complications, so it cannot meet the clinical needs

Method used

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  • Cream preparation for preventing and curing mammary gland hyperplasia and preparation method thereof
  • Cream preparation for preventing and curing mammary gland hyperplasia and preparation method thereof
  • Cream preparation for preventing and curing mammary gland hyperplasia and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] (1) preparation is used to prevent and treat the cream of mammary gland hyperplasia

[0044](1) Preparation of medicinal extract: add 1.7L of ethanol solution with a volume percentage of 75% to 50g roses, 50g cloves, 50g Yuanhu, 50g buliuxing, 50g Sperancae and 50g rhubarb and heat to reflux for extraction 1h (70-80°C), 3 times in total, separate the extract from the dregs, combine the extracts, and then follow the steps below:

[0045] ① Reflux the extract in a water bath at 82°C, collect the filtrate and ethanol, and recycle the ethanol;

[0046] ②Decoct the dregs with water, add 6 times the weight of water, and decoct for 30 minutes each time; decoct twice, and combine the decoction; concentrate the decoction into a paste, and add 2 times the volume to the paste 95% ethanol solution, mix well and let stand for 24 hours, filter, remove the precipitate, and collect the filtrate;

[0047] 3. the filtrate obtained by steps 1. and 2. is combined, and the filtrate is con...

Embodiment 2

[0134] (1) preparation is used to prevent and treat the cream of mammary gland hyperplasia

[0135] (1) Preparation of medicinal extract: add 1.4L ethanol solution with a volume percentage of 75% to 50g rose, 50g clove, 50g Yuanhu, 50g buliuxin, 25g Sperantheca and 25g rhubarb, and heat at 70-80°C Reflux for extraction, 3 times in total, 1 hour each time, separate the extract from the dregs, combine the extracts, and then follow the steps below:

[0136] ① Reflux the extract in a water bath at 80°C, collect the filtrate and ethanol, and recycle the ethanol;

[0137] 2. with embodiment 1 step (one) (1) 2.;

[0138] 3. step (1) (1) 3. of embodiment 1, obtain medicinal extract 50g;

[0139] (2) Preparation of matrix: with step (1) (2) of embodiment 1;

[0140] (3) Blending medicine: prepare all the medicinal extracts obtained in step (1) and 200 g of the matrix obtained in step (2); the first choice is to heat and melt the matrix at 60° C., and add the medicinal extracts under...

Embodiment 3

[0159] (1) preparation is used to prevent and treat the cream of mammary gland hyperplasia

[0160] (1) Preparation of medicinal extract: add 1.1L of ethanol solution with a volume percentage of 75% to 25g of roses, 25g of cloves, 25g of Rhizoma chinensis, 25g of buliu xing, 50g of Sperantheca sativa and 50g of rhubarb, and heat at 70-80°C Reflux for extraction, 3 times in total, 1 hour each time, separate the extract from the dregs, combine the extracts, and then follow the steps below:

[0161] ① Reflux the extract in a water bath at 85°C, collect the filtrate and ethanol;

[0162] 2. with embodiment 1 step (one) (1) 2.;

[0163] 3. with embodiment 1 step (one) (1) 3., obtain medicinal extract 40g;

[0164] (2) Preparation of matrix: with step (1) (2) of embodiment 1;

[0165] (3) Blending medicine: prepare all the medicinal extracts obtained in step (1) and 160g of the matrix obtained in step (2); the first choice is to heat and melt the matrix at 70°C, and add the medic...

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Abstract

The invention discloses a cream preparation for preventing and curing mammary gland hyperplasia and a preparation method thereof. The cream preparation comprises the active constituents of flos rosae rugosae, syzygium aromaticum, rhizoma corydalis, cowherb seeds, garden balsam stems, rheum officinale, musk and borneol. The preparation method comprises the following steps of: extracting the flos rosae rugosae, the syzygium aromaticum, the rhizoma corydalis, the cowherb seeds, the garden balsam stems and the rheum officinale through an alcohol solution, and leaching the solution to remove alcohol to obtain a filter liquor; decocting medicine dregs with water to obtain a decoction liquor; combining the filter liquor and the decoction liquor to obtain a drug extract; uniformly mixing the drug extract with a substrate; and then adding the borneol and the musk to obtain the cream preparation for preventing and curing the mammary gland hyperplasia. The cream preparation has the advantage of precise and appropriate compatibility and the effects of smoothing the liver, relieving stasis, promoting the flow of qi and blood circulation, eliminating stagnations and stopping pains, can obviously control the mammary gland hyperplasia, reduce and regulate the contents of estrogen and progesterone in the blood and down regulating the expression of mammary gland hyperplasia tissues AP-2alpha and C-erbB-2 so as to achieve the purposes of treating the mammary gland hyperplasia and preventing breast cancer.

Description

technical field [0001] The invention particularly relates to a cream for preventing and treating mammary gland hyperplasia and a preparation method thereof, belonging to the field of traditional Chinese medicine. Background technique [0002] Hyperplasia of Mammary Gland (HMG) is the most common breast disease, with breast pain and lumps as the main clinical manifestations, and presents periodic changes with the menstrual cycle or mood swings, which is characterized by a long course and slow progress. It is easy to relapse, and it is prone to canceration in severe mammary gland hyperplasia and atypical mammary gland hyperplasia. The probability of breast cancer is twice as high as that of normal healthy women. Hyperplasia of mammary glands can occur in women of any age stage after the onset of puberty, and is the most common breast disease in women, and its incidence rate accounts for the first place in breast diseases. In recent years, the incidence of the disease has been...

Claims

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Application Information

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IPC IPC(8): A61K36/738A61K9/06A61K47/12A61P15/14A61K31/045A61K35/55
Inventor 马民张桂娟李德辉
Owner JINAN UNIVERSITY
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