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Anti-anxiety pharmaceutical composition

A composition and anti-anxiety technology, which can be used in drug combinations, pharmaceutical formulations, plant raw materials, etc., can solve problems such as easy addiction, memory loss, and curative effect.

Active Publication Date: 2011-06-08
BEIJING UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Long-term use is prone to addiction and tolerance, and there are adverse reactions such as memory loss, gastrointestinal reactions, and curative effect reduction

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0131] Embodiment 1: Capsules

[0132] Spider incense 12g Albizia juniper skin 9g

[0133] 9g wild jujube kernels 1g rushes

[0134] Take the spider incense and grind it into a coarse powder, use 35% ethanol equivalent to 10 times by weight of the spider incense medicinal material, and reflux extract it for 3 times, each time for 1 hour; grind the jujube seed and the bark of Albizia Julibrissin into a coarse powder, add 10 times by weight of water, Reflux extraction 3 times, 2 hours each time; crush the rushes into coarse powder, use 50 times by weight of 95% ethanol, reflux extraction 3 times, 1 hour each time; recover the solvent from the above extracts respectively, concentrate them into dry paste, and The components of the dry paste are mixed according to the prescription ratio, add dextrin 0.5 times the amount of dry paste by weight, mix well, 90% ethanol is used as a wetting agent, and granulate, pass through a 20-mesh sieve, and the granules should be kept below the cr...

Embodiment 2

[0135] Embodiment 2: tablet

[0136] Spider Incense 8g Albizia Peel 12g

[0137] Stir-fried jujube kernels 14g rush grass 0.8g

[0138] Freeze and pulverize the spider incense medicinal material, use 35% ethanol equivalent to 6 times the weight of the spider incense medicinal material, and reflux extract 3 times, each time for 1 hour, and recover the ethanol to form a dry paste; mix the dried coarse powder of Albizia julibrissin with the fried Chinese date seed medicinal material, add 12 times the weight of water, decocting 3 times, 2 hours each time, combining the filtrate, and concentrating into a dry paste; refluxing the whole rush grass with 45 times the weight of 95% ethanol for 4 times, 2.5 hours each time, recovering the ethanol to form a dry paste ; Mix the above dry pastes, add conventional auxiliary materials, and make tablets according to conventional processes.

Embodiment 3

[0139] Embodiment 3: pill

[0140] Spider incense 18g Albizia juniper skin 6g

[0141] Stir-fried Suanzaoren 8g Rush 1.2g

[0142] Freeze and pulverize the medicinal material of Spider Fragrance, use 35% ethanol equivalent to 12 times the weight of the medicinal material of Spider Fragrance, extract 3 times under reflux, 1 hour each time, and recover the ethanol to form a dry paste; mix the dry coarse powder of Albizia Julibrissin with the medicinal material of Fried Jujube Seed, add 8 times the weight of water, decocting once for 3.5 hours each time, combining the filtrates, and concentrating into a dry paste; refluxing and extracting the whole rush grass with 56 times the weight of 95% ethanol twice, each time for 1 hour, recovering the ethanol to form a dry paste ; Mix the above dry pastes, add conventional auxiliary materials, and make pills according to conventional processes.

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PUM

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Abstract

The invention discloses an anti-anxiety pharmaceutical composition which is prepared from the following raw medicines: jatamans valeriana rhizome, cortex albiziae, spina date seed and juncus communis. By using the pharmaceutical composition disclosed by the invention for carrying out a mouse elevated plus-maze test, a light and dark box test, an independent activity test, a nikethamide-induced mouse convulsion test, a rat elevated plus-maze test, a rat Vogel test, a rat independent drinking test and a pain threshold test, the test results show that the pharmaceutical composition and capsules disclosed by the invention have obvious anti-anxiety effects and have no calming effects or side effects.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to an anti-anxiety pharmaceutical composition. Background technique [0002] Anxiety disorder is a neurosis characterized by recurrent episodes of acute anxiety, including generalized anxiety and panic disorder, often accompanied by dizziness, chest tightness, palpitations, dyspnea, dry mouth, frequent urination, urgency, sweating, and tremors And motor restlessness, and sleep disorders, etc., accompanied by autonomic dysfunction. With the development of modern society, people's pace of life is generally accelerated, and the pressure from society, life and work is increasing, so the number of patients with anxiety disorders is increasing day by day. [0003] Anxiolytic drugs commonly used in clinical practice are divided into benzodiazepines and non-benzodiazepines. Benzodiazepines such as chlordiazepoxide (chlordiazepoxide), diazepam, and nitrazepam; non-benzodiazepines such as bus...

Claims

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Application Information

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IPC IPC(8): A61K36/88A61P25/22
Inventor 石晋丽刘勇郑虎占郭建友赵保胜王延丽彭敏翟玉静
Owner BEIJING UNIV OF CHINESE MEDICINE
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