Salicylic acid metformin salt and preparation method and medical application thereof
A technology of metformin salicylate and metformin, which is applied in the field of metformin salicylate and the preparation of such salt compounds, and can solve problems such as incompleteness
Inactive Publication Date: 2011-06-15
CHINA PHARM UNIV
View PDF3 Cites 12 Cited by
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
The absorption of metformin is saturated and very incomplete
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View moreImage
Smart Image Click on the blue labels to locate them in the text.
Smart ImageViewing Examples
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0034] Hemimetformin Salicylate
[0035]
[0036] Dissolve 10g (72.40mmol, 10eq) of salicylic acid in 35ml of ethanol, then add 0.93g (7.24mmol) of metformin, and stir at room temperature. Heat up to 90°C to dissolve the reactant, filter, cool and crystallize the filtrate, filter with suction, and dry to obtain a white solid product which is hemimetformin salicylate. M.p.136-140°C. 1 H NMR (DMSO-d 6 , 300MHz) δ2.93(s, 3H), 6.56(s, 2H), 6.89-6.95(m, 2H), 7.18(s, 1H), 7.47-7.53(m, 1H), 7.77-7.80(dd, 1H, J = 1.83Hz and 7.86Hz).
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More PUM
Login to View More Abstract
The invention relates to the field of medicinal chemistry, in particular to a novel salicylic acid metformin salt. A salt compound can be applied to the preparation of a medicament for treating diabetes and complications of diabetes, a medicament for treating cerebral ischemia, a medicament for treating cardiovascular diseases, medicaments for treating thrombus and atherosclerosis or a medicament for treating metabolic syndrome. The invention also relates to a method for preparing the salt compound.
Description
technical field [0001] The invention relates to the field of medicinal chemistry, in particular to a novel metformin salicylate salt. The salt compound can be used for the preparation of anti-diabetes and its complications, anti-cerebral ischemia, anti-cardiovascular disease, antithrombotic, anti-atherosclerosis or treatment of metabolic syndrome. The present invention also relates to the preparation method of the salt compound. Background technique [0002] Metformin is an oral drug for the treatment of type 2 diabetes. It has been used in the treatment of type 2 diabetes for more than 50 years. It belongs to the biguanide hypoglycemic drug and does not stimulate the secretion of insulin by pancreatic β cells. It is mainly used for obese non-insulin-dependent mild diabetic patients. Its general mechanism of action includes: (1) increasing the sensitivity of peripheral tissues to insulin; (2) inhibiting hepatic gluconeogenesis and reducing the output of glycogen; (3) It ca...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More Application Information
Patent Timeline
Login to View More Patent Type & Authority Applications(China)
IPC IPC(8): C07C277/08A61P9/06A61P3/10A61P9/10A61P7/02A61K31/60A61P3/00C07C65/10C07C51/41C07C279/26
Inventor 孙宏斌张迎霞洪浩
Owner CHINA PHARM UNIV