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Preparation technology of integrated ephedra, aconite and asarum decoction novel dosage form

An integrated and new dosage form technology of Asarum Decoction, which is applied in the direction of anti-inflammatory agents, anti-virus agents, anti-bacterial drugs, etc., to achieve the effect of wide target distribution

Inactive Publication Date: 2011-06-22
SUZHOU ZHIWEITANG BIOLOGICAL TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no identical or similar literature reports at home and abroad

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Prepare the following raw materials by the aforementioned method:

[0042] Extracts, nanoparticles, microcapsules, nanoparticles.

[0043] The composition of the raw materials used to make the active ingredients is——

[0044]6 parts of ephedra, 9 parts of aconite, 6 parts of asarum

[0045] Its manufacturing process is as follows:

[0046] In the GMP10000 clean room, the extract, nanoparticles, microcapsules, and nanoparticles are mixed according to the ratio of 4:2:2:2, and the latest version of the "Chinese Pharmacopoeia" preparation part of the hard capsule standard is adopted, without adding excipients, antiseptic The preparation is filled with hard capsules by a full-automatic capsule filling machine to make hard capsules. Then carry out internal and external packaging such as counting, bottling, sealing, pasting labels, coding, and packing. Finally, according to the production batch uniform instant sterilization, and issue a sterilization report.

Embodiment 2

[0048] Prepare the following raw materials by the aforementioned method:

[0049] Water decoction concentrate, nanoliposome, nanoemulsion, microemulsion, nanosuspension.

[0050] The composition of the raw materials used to make the active ingredients is——

[0051] 6 parts of ephedra, 9 parts of aconite, 6 parts of asarum

[0052] Its manufacturing process is as follows:

[0053] In the GMP10000 clean room, the decoction concentrate, nanoliposome, nanoemulsion, microemulsion, and nanosuspension are mixed according to the ratio of 5:1:1:2:1, and the latest version of "Chinese Pharmacopoeia" is used. Part of the soft capsule standard, without adding auxiliary materials and preservatives, adopts a fully automatic soft capsule filling machine to sub-pack soft capsules to make soft capsules. Then carry out internal and external packaging such as counting, bottling, sealing, pasting labels, coding, and packing. Finally, according to the production batch uniform instant steriliza...

Embodiment 3

[0055] Prepare the following raw materials by the aforementioned method:

[0056] Extract, solid lipid nanoparticles, nanoemulsion.

[0057] The composition of the raw materials used to make the active ingredients is——

[0058] 6 parts of ephedra, 9 parts of aconite, 6 parts of asarum

[0059] Its manufacturing process is as follows:

[0060] In the GMP10000 clean room, the extract, solid lipid nanoparticles, and nanoemulsions are mixed in a ratio of 4:3:3, and the latest version of the "Chinese Pharmacopoeia" preparation part of the film standard is adopted, and the film-forming material is polyvinyl alcohol. Made into a film. Cartoning, sealing, sticking labels, printing codes, packing and other internal and external packaging. Finally, according to the production batch uniform instant sterilization, and issue a sterilization report. The area of ​​each film is 2-40 square centimeters, the drug content is 1.2-5 grams, and each film is applied for 12-72 hours. The applica...

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Abstract

The invention relates to a preparation technology of an integrated ephedra, aconite and asarum decoction novel dosage form. The novel dosage form comprises the following active ingredients in parts by weight: 6 parts of ephedra, 9 parts of aconite and 6 parts of asarum. The production process comprises the following steps: extraction in aqueous alcohol, ultrasonic grinding and extraction, microwave extraction, decoction in water and concentration, spray drying, high-pressure homogenizing, nanoscale grinding, nanoparticle preparation and the like. In the method, the stress is laid on the advantages of multi-synergy and multi-target effects of nano traditional Chinese medicines. After scale industrial production, the production cost can be substantially lowered, the product quality can be improved and the targeting and slow / controlled release properties of the medicines are stronger. After the novel dosage form is prepared into films, the films can be stuck to the skins of the human bodies and are used for treating the diseases through percutaneous absorption.

Description

technical field [0001] The invention relates to a new integrated dosage form of Mahuangfuzixixin Decoction, and also relates to a preparation technology for a new integrated dosage form of Mahuangfuzi Xixin Decoction. Background technique [0002] The development level of new drugs and new dosage forms can reflect the economic and technical strength of a country's pharmaceutical industry. The backwardness of the level of preparations not only affects the efficacy of drugs, but also leads to low added value of drugs, which directly affects market competition and industrial economic benefits. This is why the number of products in my country's pharmaceutical industry ranks among the top in the world and the output value is only equivalent to one or two multinational pharmaceutical companies. One of the main reasons. In view of my country's national conditions, oral preparations account for about 2 / 3 of various systemic drug preparations, and accelerating the development and pro...

Claims

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Application Information

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IPC IPC(8): A61K36/714A61K9/00A61P9/00A61P9/02A61P9/06A61P9/12A61P11/00A61P11/02A61P13/12A61P21/04A61P29/00A61P31/04A61P37/08A61P39/00A61P43/00
Inventor 杨洪舒
Owner SUZHOU ZHIWEITANG BIOLOGICAL TECH
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