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Pre-emulsified propylgallate concentrate and preparation thereof

A concentrated solution and pre-emulsification technology, which is applied in the direction of emulsion delivery, blood diseases, extracellular fluid diseases, etc., can solve the problems that other drugs cannot be self-emulsified

Active Publication Date: 2011-06-29
HUNAN KELUN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, drugs often have a significant impact on the self (micro) emulsification system, which leads to different drugs requiring different types and proportions of excipients. Only some special combinations can achieve self (micro) emulsification. Combinations of marketed products or literature reports are combined. Cannot achieve self-emulsification of other drugs

Method used

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  • Pre-emulsified propylgallate concentrate and preparation thereof
  • Pre-emulsified propylgallate concentrate and preparation thereof
  • Pre-emulsified propylgallate concentrate and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0144] Propyl gallate 5g Caprylic monoglyceride 10g Polysorbate 60 60g Polyethylene glycol 800 25g Vitamin E acetate 0.05g

[0145] Propyl gallate, caprylic monoglyceride, polysorbate 60, and polyethylene glycol are mixed according to the ratio to fully dissolve the propyl gallate to obtain a pre-emulsified concentrated solution; vitamin E acetate is added, and the clinical preparation is made according to the conventional process. acceptable soft capsules.

Embodiment 2

[0147] Propyl gallate 10g Caprylic capric triglyceride 10g Polysorbate 80 10g α-tocopheryl acetate 10g Polyethylene glycol 400 15g Ethanol 1g Tetrasodium edetate 0.05g

[0148] Dissolve propyl gallate in a mixed solution of polyethylene glycol and ethanol, add 0.05 g of sodium calcium edetate, and then mix evenly with caprylic capric triglyceride and polyoxyethylene 35 castor oil to obtain a pre-emulsified concentrated solution; Clinically acceptable capsules are prepared according to conventional techniques.

Embodiment 3

[0150] Propyl gallate 10g Capric diglyceride 40g Polyoxyethylene 40 Castor oil 40g Polyethylene glycol 300 10g Calcium sodium edetate 0.01g

[0151] Propyl gallate was dissolved in a mixed solution composed of capric diglyceride, polyoxyethylene 40 castor oil and polyethylene glycol to obtain a pre-emulsified concentrated solution; 0.01 g of disodium edetate was added, followed by a conventional process , to make a clinically acceptable oral solution.

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PUM

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Abstract

The invention discloses pre-emulsified propylgallate concentrate for treating cardiovascular diseases as well as the preparation method and pharmaceutical application thereof. The pre-emulsified concentrate comprises propylgallate, oil phase, surfactant, latent solvent, and the like and is used for treating ischemic cerebrovascular diseases such as acute cerebral infarction, chronic cerebral thrombosis, lacunar cerebral infarction and cerebral vascular insufficiency as well as brain coma sequela, cerebral trauma, cerebral concussion, coronary heart disease, angina pectoris, hypertension, congestive heart failure, pulmonary heart disease and peripheral angiopathies such as thrombophlebitis, and the like.

Description

technical field [0001] The invention relates to an emulsified concentrate and its preparation, in particular to a propyl gallate pre-emulsified concentrate for treating cardiovascular and cerebrovascular diseases and its preparation, preparation method and application. Background technique [0002] Propyl gallate (Chishao 801) is an anti-platelet active ingredient, propyl gallate, which was isolated from the traditional Chinese medicine Radix Paeoniae Rubra by Chinese scientists and technicians in the 1970s and 1980s. It was first approved in 2003. Propyl gallate is currently widely used in 1. Ischemic cerebrovascular diseases (such as acute cerebral infarction, chronic cerebral thrombosis, lacunar infarction, cerebral insufficiency), sequelae of cerebral coma, brain trauma, concussion; 2. Coronary heart disease , angina pectoris, hypertension, heart failure; 3. Pulmonary heart disease; 4. The treatment of certain peripheral vascular diseases (such as thrombophlebitis) can s...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K31/235A61K47/34A61K47/44A61P9/10A61P7/02A61P9/12A61P9/04A61P9/14A61K47/10A61K47/14A61K47/26
Inventor 蔡勤
Owner HUNAN KELUN PHARMA
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