Compositions for pulmonary delivery of premedication

A composition and material technology, applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc.

Inactive Publication Date: 2011-07-20
GLAXO GRP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Additionally, increased TNF-α expression may be temporally associated with exacerbation in COPD patients (previously cited Calikoglu et al., 2004)

Method used

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  • Compositions for pulmonary delivery of premedication
  • Compositions for pulmonary delivery of premedication
  • Compositions for pulmonary delivery of premedication

Examples

Experimental program
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Embodiment

[0134] The selection and characterization of lead molecules for domain antibodies against human TNFR1 are detailed below:

[0135]The domain antibodies generated were derived from Domantis' phage library. Soluble selection and panning for passively adsorbed human TNFRl was performed according to the relevant standard Domantis method. Human TNFR1 was purchased as a soluble recombinant protein from R&D Systems (Cat. No. 636-R1-025 / CF) or Peprotech (Cat. No. 310-07) or used directly (in the case of passive selection) or in the presence of primary amine-mediated After coupling biotinylation, its activity was followed by biological assay quality control, and its molecular weight and biotinylation degree were analyzed by mass spectrometry. Typically, 3 rounds of selection are performed using reduced antigen levels for each subsequent round.

[0136] The selection output was screened by phage ELISA for the presence of anti-TNFRl binding clones. DNA was isolated from these phage se...

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Abstract

The present invention relates to methods of direct pulmonary delivery of polypeptides e.g. of domain antibodies, and to particular polypeptide compositions suitable for direct pulmonary delivery. The invention also relates to use of such compositions in medicine, e.g. for the treatment and diagnosis of lung disease, for example for treating Chronic Obstructive Pulmonary Disease (COPD) and asthma.

Description

[0001] The present invention relates to methods of direct pulmonary delivery of polypeptides, such as domain antibodies, and to specific polypeptide compositions suitable for direct pulmonary delivery. The invention also relates to the use of such compositions in medicine, for example for the treatment and diagnosis of pulmonary diseases, for example for the treatment of chronic obstructive pulmonary disease (COPD) and asthma. Background of the invention [0002] Therapeutic or diagnostic agents are often unable to penetrate into tissues or organs and thus fail to produce the desired therapeutic or diagnostic effect where it is specifically needed. [0003] Therefore, there is a need for methods of administering such therapeutic or diagnostic agents directly to tissues or organs, such as lung tissue, such that the agent produces a longer therapeutic window. [0004] There is also a need for specific compositions comprising therapeutic or diagnostic agents that are particularly...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K16/00C07K16/22C07K16/28
CPCC07K16/22A61K2039/541C07K2317/569C07K2317/92C07K2317/21C07K16/244A61K2039/505C07K16/2878C07K2316/96A61P11/00A61P43/00C07K2317/76
Inventor A·巴斯兰N·D·布鲁伊斯C·A·斯帕克斯
Owner GLAXO GRP LTD
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