Amygdalin gel and preparation method and medicinal application thereof

Abstract

The invention discloses amygdalin gel and a preparation method and medicinal application thereof, belonging to medicinal preparations containing organic active components. The preparation method comprises the following steps of: adding distilled water to 1-15% of amygdalin as a medicinal material till dissolution; adding 0.5-10% of a high polymer host material carbomer for fully swelling; then respectively adding 1-25% of glycerol as a humectant, 0.5-20% of propylene glycol as a penetrating agent, 0.05-0.2per mill of ethyl p-hydroxybenzoate as a preservative and 0.01-0.2% of disodium ethylene diamine tetraacetate as a stabilizer; regulating the pH to 6.0-8.0 by 0.5-3% of triethanolamine; finally adding distilled water to 100%; and fully stirring to form gel. The amygdalin gel prepared by the preparation method has no irritation and allergization on skin, can release the medicament stably and persistently, and has high bioavailability and satisfactory percutaneous infiltration rate, so that the amygdalin gel becomes a new external medicinal preparation.

Description

technical field [0001] The invention belongs to pharmaceutical preparations containing organic active ingredients, in particular to an amygdalin gel, a preparation method thereof, and a medical application of the gel. Background technique [0002] Bitter almond is a traditional Chinese medicine recorded in the Chinese Pharmacopoeia. The research on bitter almond and its preparations at home and abroad has a history of nearly 200 years. As early as 1830, Robiquet and others isolated amygdalin from it. So far, it has become a commonly used expectorant and antitussive agent in medicine, as well as an auxiliary anticancer drug. Amygdalin is widely found in the seeds of various Rosaceae fruits such as apricots, peaches, plums, and hawthorns, especially in bitter almonds, which is about 2%-3%. [0003] "New Drugs and Clinics" 1986; 5 (3): 141-143, published "A preliminary study on the pharmacokinetics and toxicology of amygdalin". The study showed that intravenous injection of am...

AI Technical Summary

Problems solved by technology

[0005] Due to the toxicity of oral drugs, the oral dose cannot be controlled, which affects the curative effect; the pharmacological research of intravenous administration is not deep enough, which may cause other potential dangers

Moreover, amygdalin has a short biological half-life and rapid excretion, requiring repeated administration

[0006] At present, there is no external preparation of amygdalin available for clinical application

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