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Birch bark extractive as well as preparation method and medical purposes thereof

A technology of birch bark and extract, applied in the direction of drug combination, pharmaceutical formula, plant raw material, etc.

Inactive Publication Date: 2013-01-09
BEIHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The present invention is the first time to obtain the active component for inhibiting protein tyrosine phosphatase 1B from white birch bark, and many pharmacological experiments have shown that the component has the activity of significantly inhibiting protein tyrosine phosphatase 1B and reducing Blood sugar effect, according to literature search, there is no report on this kind of plant

Method used

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  • Birch bark extractive as well as preparation method and medical purposes thereof
  • Birch bark extractive as well as preparation method and medical purposes thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Embodiment 1 (best embodiment)

[0053] Dried chopped birch ( Betula platyphylla Suk) bark 500 g, heated and refluxed with 5 times the amount of 80% methanol to extract 3 times, refluxed for 60 minutes each time, combined the extracts, recovered the methanol under pressure to obtain a concentrated solution, further placed in an open container to heat and volatilize the methanol, and put Cool, add 1 times the amount of water, a large amount of precipitate precipitates, and extract the concentrate by suction filtration; the concentrate is adjusted to a suspension with 2 times the amount of water, extracted 3 times with 1 times the amount of dichloromethane, combined extracts, and reduced pressure Recover dichloromethane and concentrate until it is difficult to concentrate. Heat it in an open container to evaporate as much dichloromethane as possible, let cool, and dry; the dried product is ground and subjected to 200-300 mesh silica gel column chromatography, firstly w...

Embodiment 2

[0055] The difference between this example and Example 1 is that each reflux time was adjusted from 60 minutes to 35 minutes, and 34.7 g of extract was obtained as a result. Among them, the content of lupeol is 22.08%.

Embodiment 3

[0057] The difference between this example and Example 2 is that each reflux time was adjusted from 35 minutes to 45 minutes, and 35.4 g of extract was obtained as a result. Among them, the content of lupeol is 22.09%.

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Abstract

The invention discloses a birch bark extractive as well as an extraction method and medical purposes thereof. The extraction method comprises the following steps of: extracting and separating birch bark to obtain a component with the resistance to PTP1B (Protein Tyrosine Phosphatase 1B) activity. Shown by multiple in-vitro restriction experiments of the PTP1B, the component has remarkable PTP1B restriction activity and can be applied to preparing medicaments for treating diabetes, obesity and complications.

Description

technical field [0001] The invention discloses a white birch bark extract and an extraction method, and also provides its medical application, and relates to the technical field of traditional Chinese medicine. Background technique [0002] At present, diabetes is often divided into two types: insulin-dependent (IDDM, type 1 diabetes) and non-insulin-dependent (NIDDM, type 2 diabetes), of which type 2 diabetes accounts for 90% of diabetes. WHO predicts that the number of people with diabetes will rise from 135 million in 1995 to 300 million by 2025 due to aging population, obesity, unhealthy diet and inactive lifestyle. [0003] Type 2 diabetes is characterized by resistance to the action of insulin in insulin-sensitive tissues such as skeletal muscle, liver, and adipose tissue. Although its specific mechanism is unclear, the weakening or even blocking of insulin signaling in its transduction pathway must be directly related. PTPases play a role in multiple links in the in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/185A61P3/04A61P3/10A61P5/50A61K129/00
Inventor 崔龙吴学李东浩苑广信孙亚楠
Owner BEIHUA UNIV
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