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Pharmaceutical composition for preventing or treating abortion

A composition and drug technology, applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., can solve the problems of blood transfusion reaction, can not be widely used, and high preparation cost, and achieve pregnancy maintenance, prevention or treatment of miscarriage, and increase of litter size. Effect

Active Publication Date: 2011-08-03
南通东湖国际商务服务有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In conclusion, in the prior art, there are many reports on traditional Chinese medicine preparations for miscarriage protection or prevention of miscarriage, but these traditional Chinese medicine compositions are generally composed of more than 10 traditional Chinese medicines, and the preparation cost is high, and the burden of medication for patients is heavy.
[0005] In addition, clinically, for spontaneous abortions caused by low maternal-fetal immune function, Western medicine often uses blood transfusion therapy, and the success rate of miscarriage is about 80%. Causes transfusion reactions, so it cannot be widely used

Method used

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  • Pharmaceutical composition for preventing or treating abortion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1 Preparation of the pharmaceutical composition for preventing or treating miscarriage

[0023] Herbal Prescription:

[0024] Angelica 100g

Paeoniae Alba 50g

Dried ginger 50g

Walnut meat 20g

Atractylodes 50g

Licorice 80g

Wolfberry 100g

Schisandra 20g

[0025] Preparation:

[0026] Weigh the above-mentioned eight-flavored Chinese crude drug of the prescribed amount, add 5 times the amount of water to decoct for 2 hours, and filter. Add 4 times the amount of water to the filter residue and decoct for 2 hours, then filter. The two filtrates were combined, left to settle for more than 12 hours, and the supernatant was concentrated below 60°C under reduced pressure until the extract contained crude drug 2g / ml. Put the extract in a stainless steel plate, vacuum dry (below 60°C), weigh the dry extract (extract rate about 15%), pulverize, add sucrose powder, make 40-mesh granule powder and pack it, 10g per pac...

Embodiment 2

[0027] Example 2 Preparation of the pharmaceutical composition for preventing or treating miscarriage

[0028] Herbal Prescription:

[0029] Angelica 80g

Paeoniae Alba 50g

Dried Ginger 60g

Walnut meat 20g

Atractylodes 50g

Licorice 100g

Wolfberry 80g

Schisandra 10g

[0030] Preparation:

[0031] Weigh the above-mentioned eight-flavored Chinese crude drug of the prescribed amount, add 5 times the amount of water to decoct for 2 hours, and filter. Add 4 times the amount of water to the filter residue and decoct for 2 hours, then filter. The two filtrates were combined, left to settle for more than 12 hours, and the supernatant was concentrated below 60°C under reduced pressure until the extract contained crude drug 2g / ml. Put the extract in a stainless steel plate, vacuum dry (below 60°C), weigh the dry extract (extract rate about 15%), pulverize, add sucrose powder, make 40-mesh granule powder and pack it, 10g per package...

Embodiment 3

[0032] Example 3 Preparation of the pharmaceutical composition for preventing or treating miscarriage

[0033] Herbal Prescription:

[0034] Angelica 12g

Paeoniae Alba 6 g

dried ginger 4 g

Walnut meat 3 g

Atractylodes 4 g

Licorice 6 g

Wolfberry 12g

Schisandra 3 g

[0035] Preparation:

[0036] Weigh the above-mentioned eight-flavored Chinese crude drug of the prescribed amount, add 5 times the amount of water to decoct for 2 hours, and filter. Add 4 times the amount of water to the filter residue and decoct for 2 hours, then filter. The two filtrates were combined, left to settle for more than 12 hours, and the supernatant was concentrated below 60°C under reduced pressure until the extract contained crude drug 2g / ml. Put the extract in a stainless steel plate, vacuum dry (below 60°C), weigh the dry extract (extract rate about 15%), pulverize, add sucrose powder, make 40-mesh granule powder and pack it, 10g per package....

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Abstract

The invention relates to a pharmaceutical composition for preventing or treating abortion, which is prepared from the following active components in parts by weight: 8-12 parts of angelica, 4-6 parts of white peony root, 4-6 parts of dried ginger, 1-3 parts of walnut kernel, 4-6 parts of bighead atractylodes rhizome, 6-10 parts of licorice, 8-12 parts of medlar and 1-3 parts of shiandra. After the pharmaceutical composition provided by the invention is poured into the stomach of a model rat, the pregnancy success ratio is obviously improved to 85-92%, and the litter size is obviously increased, so that the pharmaceutical composition provided by the invention can provide a favorable microenvironment for blastocyst implantation by regulation and control effects on a maternal-fetal interface endocrine-immune network, thereby maintaining pregnancy and further achieving the purpose of preventing or treating abortion.

Description

[0001] technical field [0002] The invention relates to a pharmaceutical composition for preventing or treating miscarriage, in particular to a pharmaceutical composition for preventing or treating miscarriage caused by abnormal immune regulation and / or endocrine function deficiency. Background technique [0003] Abortion is a common and frequently-occurring disease in gynecology. Its etiology is complex. The most common causes are immune factors, endocrine factors, infection factors, cervical insufficiency, uterine lesions, and genetic factors. Normal regulation of maternal immunity plays a very important role in maintaining pregnancy, while abnormal regulation of maternal immunity is the most common cause of miscarriage, and often coexists with endocrine abnormalities. At present, about 90% of the causes are related to abnormal maternal-fetal immune regulation and / or endocrine insufficiency, which has seriously affected women's physical and mental health, so it has become...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61P15/06
Inventor 李艳飞沈庆娟
Owner 南通东湖国际商务服务有限公司
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