Method for measuring weight of powder filled in capsule through comparison

A measurement method and capsule technology, applied in the direction of volume measurement instrument/method, container/cavity measurement, measurement device, etc., can solve the problems of limited capsule weight monitoring, difficult maintenance, high maintenance cost, etc., to facilitate promotion The effect of using, the method is simple and feasible, and the equipment cost is low

Inactive Publication Date: 2011-08-17
韩杰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The weighing process of various mechanical balances and electronic balances requires manual operation. The disadvantages are: slow detection speed, low efficiency, and cumbersome operation; online automatic weighing cannot be realized, and it can only be used for random inspection, and it is impossible to realize capsule-by-capsule Weighing, this method is extremely limited in monitoring the capsule grain weight, and there are still man

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0025] Example one:

[0026] According to the prepared standard of known grain weight (the weight of the powder in the capsule) and the specifications of the reference capsule, the test capsule of the same model is subjected to isovolumetric treatment, that is: the length of the test capsule is adjusted to the same as the standard reference capsule . After the capsule is filled under normal pressure, in addition to the powder, there will be a part of normal pressure air (1 atmosphere) more or less, because the same type of capsule has the same diameter, the same cross-sectional area, and the capsule body cap The shape and volume of the spherical cap at the end are also exactly the same, so for the same type of capsule with the same compression length, the total volume is the same, that is, the total volume of the internal space occupied by the powder is equal to the sum of the air volume ; For the sake of convenience, the following calculation does not consider the volume of the...

Example Embodiment

[0031] Embodiment two:

[0032] According to the specifications of the capsule to be tested, a standard capsule of the same model with the same length is selected as the reference capsule, and the capsule to be tested and the standard capsule are placed in a closed container and filled with compressed gas of N atmospheres. The subsequent steps are exactly the same as in the first embodiment. . Similarly, the particle weight of the capsule to be tested is calculated based on the length difference of the expanded capsule, the ratio N of compressed gas pressure to normal pressure, the density of the powder, the cross-sectional area of ​​the capsule cavity, and the weight of the standard capsule.

[0033] The difference between this embodiment and the first embodiment is that in the first step, when selecting the reference capsule, it is no longer any standard capsule, but the length of the capsule to be tested is taken as a selection requirement, so that there is no need to perform is...

Example Embodiment

[0034] Embodiment three:

[0035] Select a standard capsule with a known grain weight, measure its length h2', and measure the length h1' of the test capsule, record the difference Δ between h1' and h2', and then put the test capsule and the standard capsule In a container, seal the container and fill the container with N atmospheres of high-pressure gas. The subsequent steps are the same as those in Example 1 and Example 2. Finally, the expanded length h1 of the test capsule and the standard capsule expansion are measured After the length h2, calculate the difference between the weight of the powder in the standard capsule and the capsule to be tested according to the following formula 2.

[0036] m2-m1=ρ*S*[(h1-h2-Δ) / (N-1)-Δ] formula 2

[0037] In the formula, m2 represents the weight of the powder in the standard capsule, m1 represents the weight of the powder in the capsule to be tested, ρ represents the density of the powder, and S represents the cross-sectional area of ​​the c...

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PUM

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Abstract

The invention relates to a method for measuring the weigh of powder filled in a capsule through comparison. In the method, the difference between the weight of powder filled in a capsule and the weight of powder filled in a standard capsule is measured by comparing the capsule with a standard capsule, wherein the comparing process comprises the following steps: putting the capsule to be measured and the standard capsule into a container, charging high-pressure (N atmospheric pressure) gas in the container, quickly discharging the high-pressure gas in the container to make the container in the normal-pressure state after the high-pressure gas penetrates into the capsule to be measured and the standard capsule, measuring the length of the expanded capsule to be measured and the expanded standard capsule after the capsule to be measured and the standard capsule expand under the action of internal and external pressure difference, and measuring the difference between the weight of the powder filled in the capsule to be measured and the weight of the powder filled in the standard capsule according to a formula. The method can realize the capsule weight sorting just by measuring capsule length and the change of the capsule length, is simple and efficient, is easy to implement, has low requirement on equipment for implementing the method and is easy to popularize.

Description

technical field [0001] The invention relates to a method for measuring the weight of medicinal powder filled in a capsule. Background technique [0002] In the field of pharmaceutical industry, due to the influence of various factors such as the stability of the capsule filling equipment itself and the characteristics of the medicinal powder itself, the weight of the medicinal powder contained in the capsule, that is, the capsule grain weight, fluctuates during the production process of the capsule. As far as drugs for diseases are concerned, the amount of drug contained in a unit dose, that is, the grain weight of each capsule must be stabilized within a narrow range, so pharmaceutical companies will strictly control and measure the grain weight of capsules, and test And remove the defective products whose grain weight does not meet the requirements. [0003] The current method of measuring the grain weight of capsules is mainly to use various mechanical balances, electron...

Claims

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Application Information

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IPC IPC(8): G01F17/00
Inventor 韩杰
Owner 韩杰
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