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Method for measuring weight of powder filled in capsule through comparison

A measurement method and capsule technology, applied in the direction of volume measurement instrument/method, container/cavity measurement, measurement device, etc., can solve the problems of limited capsule weight monitoring, difficult maintenance, high maintenance cost, etc., to facilitate promotion The effect of using, the method is simple and feasible, and the equipment cost is low

Inactive Publication Date: 2011-08-17
韩杰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The weighing process of various mechanical balances and electronic balances requires manual operation. The disadvantages are: slow detection speed, low efficiency, and cumbersome operation; online automatic weighing cannot be realized, and it can only be used for random inspection, and it is impossible to realize capsule-by-capsule Weighing, this method is extremely limited in monitoring the capsule grain weight, and there are still many capsules whose grain weight does not meet the requirements cannot be detected
Although various devices using the principle of weight sensors have greatly improved their work efficiency and can weigh capsules one by one, they also have significant disadvantages: the equipment is precise and expensive, which is not conducive to promotion in pharmaceutical companies; the system is complex and difficult to maintain. , high maintenance cost

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] According to the specifications of the prepared standard reference capsule with known grain weight (the weight of the powder filled in the capsule), the same type of capsule to be tested is subjected to equal volume treatment, that is, the length of the capsule to be tested is adjusted to be the same as the standard reference capsule . After the capsule is filled under normal pressure, there will be more or less normal pressure air (1 atmosphere) in the interior besides the medicine powder. Because the capsules of the same type have the same diameter, the same cross-sectional area, and the capsule cap The shape and volume of the spherical cap at the end are also exactly the same, so for capsules of the same type with the same pressing length, the total volume is the same, that is to say, the volume of the internal space occupied by the powder is equal to the sum of the volume of the air ; For the sake of convenience, the volume of the spherical cap at the end of the cap...

Embodiment 2

[0032] According to the specifications of the capsule to be tested, select a standard capsule of the same model with the same length as the reference capsule, put the capsule to be tested and the standard capsule into an airtight container and fill it with compressed gas of N atmospheres, and the subsequent steps are exactly the same as in Example 1. . The grain weight of the capsule to be tested is also calculated based on the length difference of the expanded capsule, the ratio N of the compressed gas pressure to the normal pressure, the density of the drug powder, the cross-sectional area of ​​the capsule inner cavity, and the grain weight of the standard capsule.

[0033] The difference between this embodiment and Embodiment 1 is that in the first step, when selecting the reference capsule, it is no longer any standard capsule, but the length of the capsule to be tested is taken as a selection requirement, so that there is no need for equal volume processing of the capsule ...

Embodiment 3

[0035]Select a standard capsule with known grain weight, measure its length h2', and measure the length h1' of the capsule to be tested, record the difference Δ between h1' and h2', and then put the capsule to be tested and the standard capsule into the In a container, seal the container and fill the container with N atmospheres of high-pressure gas, the subsequent steps are consistent with those in Embodiment 1 and Embodiment 2, and finally measure the expanded length h1 of the capsule to be measured and the expanded length of the standard capsule. After the length h2, calculate the difference between the weight of the powder in the standard capsule and the capsule to be tested according to the following formula 2.

[0036] m2-m1=ρ*S*[(h1-h2-Δ) / (N-1)-Δ] Formula 2

[0037] In the formula, m2 represents the weight of the powder filled in the standard capsule, m1 represents the weight of the powder filled in the capsule to be tested, ρ represents the density of the powder, and S...

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Abstract

The invention relates to a method for measuring the weigh of powder filled in a capsule through comparison. In the method, the difference between the weight of powder filled in a capsule and the weight of powder filled in a standard capsule is measured by comparing the capsule with a standard capsule, wherein the comparing process comprises the following steps: putting the capsule to be measured and the standard capsule into a container, charging high-pressure (N atmospheric pressure) gas in the container, quickly discharging the high-pressure gas in the container to make the container in the normal-pressure state after the high-pressure gas penetrates into the capsule to be measured and the standard capsule, measuring the length of the expanded capsule to be measured and the expanded standard capsule after the capsule to be measured and the standard capsule expand under the action of internal and external pressure difference, and measuring the difference between the weight of the powder filled in the capsule to be measured and the weight of the powder filled in the standard capsule according to a formula. The method can realize the capsule weight sorting just by measuring capsule length and the change of the capsule length, is simple and efficient, is easy to implement, has low requirement on equipment for implementing the method and is easy to popularize.

Description

technical field [0001] The invention relates to a method for measuring the weight of medicinal powder filled in a capsule. Background technique [0002] In the field of pharmaceutical industry, due to the influence of various factors such as the stability of the capsule filling equipment itself and the characteristics of the medicinal powder itself, the weight of the medicinal powder contained in the capsule, that is, the capsule grain weight, fluctuates during the production process of the capsule. As far as drugs for diseases are concerned, the amount of drug contained in a unit dose, that is, the grain weight of each capsule must be stabilized within a narrow range, so pharmaceutical companies will strictly control and measure the grain weight of capsules, and test And remove the defective products whose grain weight does not meet the requirements. [0003] The current method of measuring the grain weight of capsules is mainly to use various mechanical balances, electron...

Claims

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Application Information

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IPC IPC(8): G01F17/00
Inventor 韩杰
Owner 韩杰
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