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Method for preparing tremellan with low molecular weight and novel medicinal application thereof

A tremella polysaccharide, low molecular weight technology, applied in the preparation of low molecular weight tremella polysaccharide, low molecular weight tremella polysaccharide field, can solve problems such as toxic side effects, normal growth and development, and metabolic effects

Inactive Publication Date: 2011-08-24
高其品
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Whether it is radiotherapy or chemotherapy, it has obvious effects on the normal growth and metabolism of the body, and has obvious toxic and side effects.

Method used

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  • Method for preparing tremellan with low molecular weight and novel medicinal application thereof
  • Method for preparing tremellan with low molecular weight and novel medicinal application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0105] Example 1 Preparation of Low Molecular Weight Tremella Polysaccharide (4800 Daltons)

[0106] Wash 1000 grams of white fungus with clean water, soak them, remove impurities after swelling, pick fruit bodies, crush them properly with a tissue grinder, add 10 liters of distilled water, add concentrated hydrochloric acid, and prepare a hydrochloric acid aqueous solution with a concentration of 0.2%. After fully stirring, Hydrolyze under high pressure at 120C for 2 hours, neutralize the acid hydrolyzate to neutrality with 20% aqueous sodium hydroxide solution, centrifuge, concentrate the supernatant to an appropriate volume, add ethanol until the alcohol concentration is 75%, centrifuge, collect the precipitate, and obtain a molecular weight of About 5,000 low molecular weight white fungus polysaccharides.

Embodiment 2

[0107] Example 2 Preparation of Low Molecular Weight Tremella Polysaccharide (1250 Dalton)

[0108] Wash 1000 grams of white fungus with clean water, soak them, remove impurities after swelling, pick fruit bodies, crush them properly with a tissue grinder, add 10 liters of distilled water, add concentrated hydrochloric acid, and prepare a hydrochloric acid aqueous solution with a concentration of 0.25%. After fully stirring, Hydrolyze under high pressure at 120C for 2.5 hours, neutralize the acid hydrolyzate to neutrality with 20% aqueous sodium hydroxide solution, centrifuge, concentrate the supernatant to an appropriate volume, add ethanol until the alcohol concentration is 75%, centrifuge, collect the precipitate, and obtain a molecular weight of About low molecular weight tremella polysaccharides.

Embodiment 3

[0109] Example 3 (capsules)

[0110] Take 200g of low-molecular-weight white fungus polysaccharide, appropriate amount of medicinal starch, mix evenly, granulate, dry, granulate, put into No. 1 capsule, and make 1000 capsules. Low molecular weight white fungus polysaccharide 2 capsules each time, 2 times a day.

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Abstract

The invention discloses a method for preparing tremellan with low molecular weight from Tremella fueiformis Berk and application of the tremellan with low molecular weight in treatment for chronic atrophic gastritis and serving as an adjuvant medicament in tumor therapy. The method for preparing the tremellan with low molecular weight comprises the following steps of: cleaning the Tremella fueiformis Berk, homogenating, adding solution of acid water, extracting for 1 to 3 hours by using the acid water at certain temperature and under certain pressure, neutralizing extracting solution of the acid water until the extracting solution is neutral by using alkaline water, centrifuging, concentrating supernatant to an appropriate volume, and preparing the tremellan through ultrafiltration membranes with different molecular weight cutoffs or an ethanol fractional precipitation method. The tremellan with low molecular weight prepared by the method is used for treating chronic atrophic gastritis and carrying out pharmacodynamics research of adjuvant medicaments in tumor therapy, and the medicinal effect is high.

Description

technical field [0001] The invention relates to a low-molecular-weight tremella polysaccharide that can treat atrophic gastritis and can be used as an auxiliary drug for tumor treatment. Specifically, it relates to a preparation method and a medical application of the low-molecular-weight tremella polysaccharide, which belongs to the field of traditional Chinese medicine. Background technique [0002] Tremella fueiformis Berk, also known as Tremella fueiformis Berk, is the dry fruiting body of Tremella tremella in the family Tremellaceae. It is a commonly used health care medicine and has the effect of nourishing yin and nourishing the lungs. It has a medicinal history of hundreds of years. Its main chemical composition is polysaccharide compound. It also contains lipids, proteins (enzymes, proteins, amino acids), inorganic salts, vitamin B complex, etc. Tremella polysaccharides are mainly acidic heteropolysaccharides with a molecular weight of about 600,000; they are mainl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00A61K31/715A61P1/04A61P35/00
Inventor 高其品姜瑞芝睢大筼陈英红高阳
Owner 高其品
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