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Melilotus officinalis total saponin, preparation method thereof and medicinal application

A technology of Osmanthus osmanthus and total saponins, which is applied in drug combinations, antipyretics, antitumor drugs, etc., to achieve the effect of expanding the scope of application and improving competitiveness

Inactive Publication Date: 2012-07-11
长春天力健康食品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is still a blank in the separation and purification technology and pharmacological activity of the total saponins of Osmanthus fruticosa at home and abroad.

Method used

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  • Melilotus officinalis total saponin, preparation method thereof and medicinal application
  • Melilotus officinalis total saponin, preparation method thereof and medicinal application
  • Melilotus officinalis total saponin, preparation method thereof and medicinal application

Examples

Experimental program
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Effect test

Embodiment 1

[0033] (1) get the dried whole grass of the goldenrod oleracea, add 40% ethanol and heat under reflux for extraction twice, 3 hours each time, combine the extracts, concentrate the extracts, and dry to obtain the extract;

[0034] (2) The extract was dissolved in water, passed through macroporous resin D101, washed with water until neutral, then eluted with 10% ethanol, until the eluent was colorless, and then eluted with 50% ethanol, and finally collected 50 % ethanol eluent is concentrated and dried to obtain the total saponins of 20% to 90% of luteolin.

Embodiment 2

[0036] (1) get the dried whole grass of the yellow flower oleracea, add 65% ethanol to heat and reflux for extraction 3 times, each time for 2 hours, combine the extracts, concentrate the extracts, and dry to obtain the extract;

[0037] (2) This extract was dissolved in water, passed through macroporous resin D201, washed with water until neutral, then eluted with 15% ethanol, until the eluent was colorless, and then eluted with 65% ethanol, and finally collected 65 % ethanol eluent is concentrated and dried to obtain the total saponins of 20% to 90% of luteolin.

Embodiment 3

[0039] (1) Take the dried whole grass of the yellow flower oleracea, add 90% ethanol and heat under reflux for extraction for 4 times, each time for 0.5 hours, combine the extracts, concentrate the extracts, and dry to obtain the extract,

[0040] (2) The extract was dissolved in water, passed through macroporous resin AB8, washed with water until neutral, then eluted with 20% ethanol, until the eluent was colorless, then eluted with 80% ethanol, and finally collected 80% ethanol. % ethanol eluent is concentrated and dried to obtain the total saponins of 20% to 90% of luteolin.

[0041] In the embodiment, the organic solvent can also be selected from methanol, ethyl acetate and acetone, the extraction method adopts ultrasonic extraction method, supercritical extraction method, immersion method and microwave method, and the macroporous resin is selected from SP825, DS401, DS100, HPD600, HPD100, DM301, DM130.

[0042] The present invention will be further described below throug...

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Abstract

The invention relates to melilotus officinalis total saponin, a preparation method thereof and medicinal application, and belongs to the field of traditional Chinese medicines. The method comprises the following steps of: drying whole herbs of melilotus officinalis, adding 40 to 90 percent of organic solvent, extracting for 2 to 4 times for 0.5 to 3 hours every time, merging extract solution, concentrating the extract solution and drying to obtain extract; and dissolving the extract in water, allowing the extract to pass through a macroporous resin column, washing until the extract is neutral, eluting by 10 to 20 percent of ethanol until eluent is colourless, eluting by using 50 to 80 percent of ethanol, collecting 50 to 80 percent of ethanol eluent, concentrating and drying to obtain themelilotus officinalis total saponin with the content of between 20 and 90 percent. The invention relates to the application of the melilotus officinalis total saponin to the preparation of medicaments for resisting inflammation, relieving swelling, stop bleeding and resisting tumors. By the preparation method, the blank of preparing the melilotus officinalis total saponin is filled up, and the application range of the melilotus officinalis total saponin in the medicinal field is expanded.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and relates to a total saponin extracted from the yellow flower oleracea, a preparation method of the total saponin and its medicinal use. technical background [0002] Melilotus.officinalis.L. is an annual or biennial herb of the genus Melilotus, also known as Melilotus. At present, there are many researches on the coumarins in the yellow-flowered oleracea, and the analgesic effects of the oleifera extract rich in coumarins and flavonoids, polyphenols and coumarins in analgesia , hemostasis and anti-inflammatory, etc. have applied for patents. Saponins are a class of glycoside compounds with high molecular weight with triterpenes or steroids as aglycones. Saponins are widely distributed in plants and are important biologically active components of many traditional Chinese medicines. They have been studied at home and abroad. popular topic. At present, the research on the separatio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/48A61P35/00A61P29/00A61P7/04
Inventor 严铭铭杨智王医术赵大庆吴岩张银玲于红威周媛
Owner 长春天力健康食品有限公司