Dendritic cell (DC)-based hepatitis B virus T epitope peptide
A hepatitis B virus and epitope peptide technology, applied in the fields of genetic engineering, biomedicine, and protein engineering, can solve problems such as inability to cure hepatitis B or other complications, and inability to effectively block liver fibrosis and sclerosis. The effect of blocking liver fibrosis and hardening and improving clinical symptoms
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[0021] The DC cell-based hepatitis B virus T epitope peptide of the present invention has an amino acid sequence of QLFHLCLII and a molecular weight of 1150.
[0022] The epitope peptide was synthesized using the standard Fmoc protocol, and after purification by HPLC, its purity was greater than 98%, see figure 1 , mass spectrometry and confirmed its molecular weight in line with the theoretical value.
[0023] The synthesis method of the hepatitis B virus T epitope peptide based on DC cells of the present invention is:
[0024] 1. Design and screening of epitope peptides
[0025] 1. Hepatitis B virus antigen
[0026] 乙型病毒抗原的核心抗原为乙肝病毒在体内引起CTL反应的主要抗原,核苷酸序列为639bp,编码蛋白为212氨基酸, MQLFHLCLIISCSCPTVQASKLCLGWLWGMDIDPYKEFGASVELLSFLPSDFFPSIRDLLDTASALYREALESPEHCSPHHTALRQAILCWGELMNLAT W VGSNLEDPASRELVVSYVNVNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQ
[0027] 2. Homology analysis
[0028] Blast the 212 amino acids with the protein fragment in the NCBI ...
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