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Application of thiolutin in the protection of nonalcoholic steatohepatitis

A technology of thiolutin and steatohepatitis, which is applied in the application field of thiolutin in the protection of non-alcoholic steatohepatitis, and can solve the blockage of phosphatidylcholine synthesis and the inability of triglycerides to be transported out of the liver , nonalcoholic steatohepatitis, etc.

Active Publication Date: 2022-03-22
ACADEMY OF MILITARY MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The lack of methionine / choline leads to the blockage of phosphatidylcholine synthesis, which in turn inhibits the secretion of very low-density lipoprotein, and very low-density lipoprotein is the carrier of fat transport out of the liver, so the inhibition of very low-density lipoprotein secretion leads to triglyceride Fat cannot be transported out of the liver, and a large amount of fat accumulates in the liver, eventually leading to the occurrence of nonalcoholic steatohepatitis
[0004] Thiolutin (also referred to as THL in this paper) is a sulfur-based microbial antibiotic produced by Streptomyces, which has broad-spectrum antibacterial activity, but its research in nonalcoholic steatohepatitis has not been reported yet

Method used

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  • Application of thiolutin in the protection of nonalcoholic steatohepatitis
  • Application of thiolutin in the protection of nonalcoholic steatohepatitis
  • Application of thiolutin in the protection of nonalcoholic steatohepatitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] This example is used to illustrate that thiolutin can improve the weight loss of mice induced by MCD model.

[0034] C57BL / 6J mice of about 8 weeks were fed with CD diet (control diet) and MCD diet (methionine / choline-deficient diet) respectively. After feeding with the feed for 2 weeks, the mice fed with the CD feed and the MCD feed were randomly divided into two groups, a control group and a thiolutin-treated group. Among them, the thiolutin-treated group was intraperitoneally injected with 2.5 mg / kg THL every other day, and the control group was injected with an equal volume of corresponding solvent every other day. The mice were treated continuously for 4 weeks, and the body weight changes of the mice were recorded every week. The result is as figure 1 shown.

[0035] Depend on figure 1 As a result, it can be seen that MCD feeding can lead to a decrease in body weight of mice. While thiolutin treatment could ameliorate the weight loss in mice induced by the MCD...

Embodiment 2

[0037] This example is used to illustrate that thiolutin can reduce the release of liver transaminase in serum.

[0038] C57BL / 6J mice of about 8 weeks were fed with CD diet (control diet) and MCD diet (methionine / choline-deficient diet) respectively. After feeding with the feed for 2 weeks, the mice fed with the CD feed and the MCD feed were randomly divided into two groups, a control group and a thiolutin-treated group. Among them, the thiolutin-treated group was intraperitoneally injected with 2.5 mg / kg THL every other day, and the control group was injected with an equal volume of corresponding solvent every other day. The mice were treated continuously for 4 weeks, and the body weight changes of the mice were recorded every week. After 4 weeks, the serum of the mice was taken to detect the levels of ALT, AST and LDH. The result is as figure 2 shown.

[0039] Depend on figure 2 It can be seen from the results that MCD feeding can cause mice to release a large amount...

Embodiment 3

[0041] This example is used to illustrate that thiolutin can reduce the accumulation of liver fat droplets in mice.

[0042] C57BL / 6J mice of about 8 weeks were fed with CD diet (control diet) and MCD diet (methionine / choline-deficient diet) respectively. After feeding with the feed for 2 weeks, the mice fed with the CD feed and the MCD feed were randomly divided into two groups, a control group and a thiolutin-treated group. Among them, the thiolutin-treated group was intraperitoneally injected with 2.5 mg / kg THL every other day, and the control group was injected with an equal volume of corresponding solvent every other day. After 4 weeks, the livers of the mice were taken and stained with oil red to detect the accumulation of fat droplets in the livers of the mice. The result is as image 3 shown.

[0043] Depend on image 3 As a result, it can be seen that MCD feeding leads to failure of hepatic fat to be transported out, and a large number of fat droplets are finally ...

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Abstract

The invention relates to the fields of biology and medicine, and discloses the application of thiolutin in the protection of nonalcoholic steatohepatitis. The inventors of the present invention found that thiolutin protected methionine / choline-deficient diet-induced non-alcoholic steatohepatitis in mice; including increasing the body weight of mice; reducing the release of transaminases in serum; and improving the accumulation of fat droplets in the liver ; Inhibit the infiltration of inflammatory cells in the liver; Block the occurrence of liver fibrosis; Therefore, it can be used as a potential drug for the prevention and / or treatment of non-alcoholic steatohepatitis.

Description

technical field [0001] The invention relates to the fields of biology and medicine, in particular to the application of thiolutin in the protection of non-alcoholic steatohepatitis: including increasing body weight; reducing the release of transaminase in serum; improving the accumulation of liver fat droplets; inhibiting liver inflammatory cells infiltration; block the occurrence of liver fibrosis. Background technique [0002] Non-alcoholic steatohepatitis, as the name implies, refers to a chronic liver disease caused by not ingesting alcohol. Nonalcoholic steatohepatitis gradually develops liver fibrosis as the disease progresses, eventually leading to liver cirrhosis and even liver cancer. Nonalcoholic steatohepatitis is the only way for nonalcoholic fatty liver disease to develop into cirrhosis or even liver cancer. Clinical data show that patients with nonalcoholic steatohepatitis have a probability of up to 20% developing into cirrhosis. It's not clear why, but nona...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/407A61P1/16A61P3/04
CPCA61K31/407A61P1/16A61P3/04
Inventor 尹荣华任广明杨晓明张文王婷刘贤李长燕詹轶群陈慧于淼高慧英赵珂
Owner ACADEMY OF MILITARY MEDICAL SCI
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