Medicinal composition for treating osteoporosis
A technology for osteoporosis and composition, which is applied in the field of pharmaceutical composition for the treatment of osteoporosis, and can solve problems such as unsatisfactory dissolution rate
Inactive Publication Date: 2011-10-05
北京美迪康信医药科技有限公司
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- Application Information
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Problems solved by technology
The patent WO9400462A1 discloses the prescription of minodronic acid preparation, which is prepared into tablets by adding lactose, cornstarch, 10% hydroxypropyl cellulose aqueous solution and magnesium stearate, but its dissolution rate is not very satisfactory. Therefore, scientific research According to the physical and chemical properties of minodronic acid, personnel need to conduct in-depth research on the preparation to obtain the ideal drug
Method used
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Embodiment 1
[0067] A pharmaceutical composition for the treatment of osteoporosis, the pharmaceutical composition is made of raw material minodronic acid, which is pulverized to 17 μm (80% particle size is less than or equal to 17 μm), mixed with pharmaceutical excipients, and prepared into tablets or capsules .
Embodiment 2
[0069] A pharmaceutical composition for the treatment of osteoporosis, the pharmaceutical composition is made of raw material minodronic acid milled to 14 μm (80% particle size is less than or equal to 14 μm) by fluid energy, mixed with pharmaceutical excipients, and prepared into tablets or capsules agent.
Embodiment 3
[0071] A pharmaceutical composition for the treatment of osteoporosis, the pharmaceutical composition is prepared from raw material minodronic acid colloidally milled to 8 μm (80% particle size is less than or equal to 8 μm), mixed with pharmaceutical excipients, and prepared into tablets or capsules .
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Abstract
The invention belongs to the field of medicaments and discloses a medicinal composition for treating osteoporosis. The medicinal composition consists of a raw material, namely minodronate, and auxiliary materials, wherein the raw material, namely the minodronate, is micronized minodronate. Deep researches of scientific researchers of the company on the physicochemical property of the minodronate show that the preparation prepared by preparing the minodronate with certain particle size obtained by micronizing the minodronate has the advantages of uniform quality and high dissolution rate.
Description
[0001] The present invention is a priority application made on the basis of the Chinese patent application number 201110077988.8. technical field [0002] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition whose raw material is micronized minodronic acid and has the function of treating osteoporosis. [0003] The micronization in the present invention refers to a method including but not limited to mechanical grinding to reduce the particle size of the raw material to 75 μm or less. The raw material particle size in the present invention means that at least 80% (more than or equal to 80% and less than 100%) of the particle size is less than or equal to 75 μm. Background technique [0004] Osteoporosis is a group of bone diseases caused by various reasons. There is normal calcification of bone tissue, and the ratio of calcium salt to matrix is normal. It is a metabolic bone lesion characterized by a decrease i...
Claims
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IPC IPC(8): A61K31/675A61K9/20A61K9/48A61P19/10
Inventor 吴劲松安鹏程
Owner 北京美迪康信医药科技有限公司