Medical application of ursolic acid-NF (Nuclear Factor)-kappaB inhibitor

Abstract

The invention provides medical application of an ursolic acid-NF (Nuclear Factor)-kappaB inhibitor and relates to application of an NF-kappaB inhibitor as an immunomodifier in the field of medicine and scientific research. As the immunomodifier, the ursolic acid-NF-kappaB inhibitor is used for preparing immunity inhibitor medicines and used in aspects of treating rejection after reducing transplantation and inducing and maintaining transplantation tolerance. As the immunomodifier, the ursolic acid-NF-kappaB inhibitor is used as antiinflammatory drugs and used for treating multiple chronic inflammatory diseases. As the immunomodifier, the ursolic acid-NF-kappaB inhibitor is used for preparing ischemia reperfusion injury protective agents and used for treating ischemia reperfusion injury diseases. As the immunomodifier, the ursolic acid-NF-kappaB inhibitor is used for preparing drugs for preventing and treating endotoxemia and septicopyemia and used for preventing and treating the endotoxemia and the septicopyemia.

Description

technical field [0001] The present invention relates to the application of an NF-kappaB inhibitor as an immunomodulator in the field of medicine and scientific research, especially in anti-transplant rejection, anti-autoimmune disease, anti-ischemia-reperfusion injury, anti-chronic inflammatory response, and anti-endotoxemia and other uses. Background technique [0002] Before the present invention was proposed, medical experts in the field knew very well that the inhibitory regulation of the immune system of the body is the key to the treatment of various diseases, such as the treatment of rejection after organ transplantation, autoimmune diseases, chronic inflammatory diseases, ischemia, etc. reperfusion injury, etc. The regulation of the immune system can start from many aspects, and the innate immune response, as a hot spot in recent research, is an excellent direction to achieve immunosuppression. [0003] The body's immune response is divided into innate immunity and...

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Problems solved by technology

[0004] At present, tens of thousands of research reports around the world have verified the importance of this molecular signal and the therapeutic effect that can be achieved after blocking it, bu

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