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Application of hydrogen physiological saline in preparation for medicine treating acute neurological damage diseases

A normal saline, acute technology, applied in the field of medicine, can solve the problems such as the application of hydrogen saline that has not been reported, achieve good therapeutic advantages, reduce the risk of side effects of drugs, and have a good effect on the treatment of acute cauda equina syndrome

Inactive Publication Date: 2011-11-02
SHANGHAI CHANGZHENG HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But there is no report about the application of hydrogen normal saline in the preparation of medicines for the treatment of acute nerve damage

Method used

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  • Application of hydrogen physiological saline in preparation for medicine treating acute neurological damage diseases
  • Application of hydrogen physiological saline in preparation for medicine treating acute neurological damage diseases
  • Application of hydrogen physiological saline in preparation for medicine treating acute neurological damage diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0095] 1. Materials and methods

[0096] (1) Animals:

[0097] Healthy male SD rats, aged 8-9 weeks, weighing 200-250g. Animals were kept in mouse cages, feeding conditions: food and drink freely, light / dark cycle of 12h / 12h, background noise less than (40±10)db, feeding temperature of (22±4)℃. The experimental animals were allowed to adapt to the environment for one week, and fasted for 12 hours before the operation.

[0098] (2) Production of hydrogen saline:

[0099] Hydrogen gas was dissolved in normal saline under 0.4 MPa pressure for 6 hours, and then stored in an aluminum bag without a cavity at normal pressure, stored in a refrigerator at 4°C, and the hydrogen normal saline was sterilized by γ-rays. In order to ensure that the hydrogen content in hydrogen saline is slightly higher than 0.6 mmol / L, hydrogen saline is prepared once a week, and the hydrogen content of hydrogen saline is detected by gas spectroscopic analysis according to the detection method of O...

Embodiment 2

[0154] Example 2 Preparation of hydrogen-containing oral liquid

[0155] Dissolve hydrogen in pure water under 0.4 MPa pressure for 6 hours to ensure that the hydrogen content in the oral liquid is slightly higher than 0.6 mmol / L, sterilize, store in an aluminum bag or aluminum tank without a cavity at normal pressure, and store at 4°C Store in the refrigerator.

Embodiment 3

[0156] Example 3 Preparation of hydrogen-containing oral liquid

[0157] Dissolve hydrogen in normal saline under the pressure of 0.4 MPa for 6 hours to ensure that the hydrogen content in the oral liquid is slightly higher than 0.6 mmol / L, sterilize, store in an aluminum bag or aluminum can without a cavity at normal pressure, and place in 4 ℃ refrigerator.

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Abstract

The invention relates to an application of hydrogen physiological saline in the preparation for a medicine treating acute cauda equine damage diseases. The invention further provides an application of a hydrogen-contained oral liquid in the preparation for a healthcare product treating acute cauda equine damage diseases. The advantages of the application of the invention are as follows: the new use of hydrogen physiological saline is developed, as well as an acute neurological damage protection function similar to that of methylprednisolone and a treatment effect to acute cauda equina syndrome of the hydrogen physiological saline are found; the hydrogen physiological saline is featured with simple preparation, high injection concentration, convenient use, no explosion risk, very low cost, no side effect and good treatment advantage, which greatly reduces the medicine side effect risk of the acute neurological damage patient and greatly decreases medical costs; the invention further develops a new use of the hydrogen-contained oral liquid, wherein the hydrogen-contained oral liquid is simply prepared, convenient for the patient to drink and with no toxic and side effects as well as great advantage to treat the acute cauda equina syndrome.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of hydrogen saline in the preparation of medicines for treating acute nerve damage diseases. Background technique [0002] Cauda equina syndrome (CES) is a group of symptoms and signs in which damage to the cauda equina nerve leads to pain in the lower extremities, motor sensory disturbance, defecation, urination, sexual function and sensory dysfunction in the saddle region. Clinically, the CES secondary to cauda equina compression is described as "full-scale outbreak syndrome". The early symptoms are relatively mild, and may only manifest as low back and leg pain. Even if the oppression of the cauda equina is relieved by surgery, most of the motor functions can be recovered, but the defecation, urination, sexual function and sensory disturbance in the saddle area are difficult to recover. Patients often cannot be operated on time due to the delay in seeing a doc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/00A61K47/02A61K47/26A61P25/00
Inventor 史建刚官正茂王元
Owner SHANGHAI CHANGZHENG HOSPITAL
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