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Method for preparing sodium quercetin-7-sulfate and application of sodium quercetin-7-sulfate to preparation of medicaments and health-care products for resisting thrombus

A technology of sulfate sodium salt and antithrombotic drug, which is applied in the application field of preparing antithrombotic drugs and health care products, and can solve problems such as undiscovered SQMS and the like

Inactive Publication Date: 2011-11-23
GUANGDONG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After searching, it is found that there is currently no literature reporting the antithrombotic function of SQMS, and there is no report on the use of SQMS as an antithrombotic drug or health care product at home and abroad.

Method used

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  • Method for preparing sodium quercetin-7-sulfate and application of sodium quercetin-7-sulfate to preparation of medicaments and health-care products for resisting thrombus
  • Method for preparing sodium quercetin-7-sulfate and application of sodium quercetin-7-sulfate to preparation of medicaments and health-care products for resisting thrombus
  • Method for preparing sodium quercetin-7-sulfate and application of sodium quercetin-7-sulfate to preparation of medicaments and health-care products for resisting thrombus

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Embodiment Construction

[0047] The preparation method of quercetin-7-sulfate sodium salt, the process steps are as follows:

[0048] 2g of quercetin was slowly added to 8mL of concentrated sulfuric acid under ice bath stirring. After stirring and reacting for 3 hours, carefully add 100ml of saturated NaCl solution dropwise under stirring, and then filter with suction. Wash the filter cake with 50ml of saturated NaCl solution until it is almost yellow. In 40ml of 50℃ hot water, filter while hot, freeze the filtrate, filter with suction, and after the filter cake is vacuum-dried, it is extracted 5 times with 100ml of absolute ethanol. The extracts are combined and concentrated to dryness. Add 20ml of 30% ethanol solution to dissolve. Cooling at room temperature, chromatography on Sephadex LH-20 column (20×300mm), gradient elution with concentration of 30%, 50%, 80% ethanol solution, press 5ml / 5 minutes, collect the eluent, and monitor the components by electrophoresis on paper , It was collected and conce...

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Abstract

The invention belongs to a method for preparing sodium quercetin-7-sulfate and application of the sodium quercetin-7-sulfate to the preparation of medicaments and health-care products for resisting thrombus. The sodium quercetin-7-sulfate is applied to the preparation of medicaments and health-care products for resisting platelet aggregation and the thrombus or is used as components of the medicaments and the health-care products for resisting the platelet aggregation and the thrombus or is used as the precursor of the medicaments for resisting the platelet aggregation and the thrombus to be transformed. The sodium quercetin-7-sulfate which is subjected to artificial semisynthesis can inhibit the platelet aggregation obviously and prevent thrombopoiesis, and has good effects of resisting the platelet aggregation and the thrombopoiesis.

Description

Technical field [0001] The invention belongs to a preparation method of quercetin-7-sulfate sodium salt and its application in preparing antithrombotic drugs and health products. Background technique [0002] Thrombotic disease is a common disease, often manifested as myocardial infarction, ischemic cerebral infarction and venous thrombosis. The investigation found that thrombotic diseases are the leading cause of death in the elderly and seriously threaten human health. At present, three types of anticoagulants, antiplatelet aggregation drugs and fibrinolytic drugs are mainly used clinically to prevent and treat thromboembolic diseases. Antiplatelet drugs have the function of inhibiting the adhesion, aggregation and release of platelets, thereby preventing thrombosis. Antiplatelet drugs can effectively prevent the occurrence of cardiovascular disease and prolong the survival period of patients. Antiplatelet drugs are increasingly used in clinical practice. However, the long-t...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P7/02A23L1/30C07D311/30
Inventor 刘文梁念慈佘戟
Owner GUANGDONG MEDICAL UNIV
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