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Process for regenerating calcium type chromatographic separation resin

A chromatographic separation and resin regeneration technology, applied in the field of calcium-type chromatographic separation resin regeneration, can solve the problems of severe acid-base pollution, large consumption of pure water, incomplete regeneration, etc., and achieve mild acid pollution, less consumption of pure water, and regeneration thorough effect

Inactive Publication Date: 2011-11-23
FUTASTE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a calcium-type chromatographic separation resin regeneration process to solve the problems of the prior art such as long regeneration time, incomplete regeneration, large consumption of pure water, severe acid-base pollution, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] 1. Rinse

[0014] Take 1500g of expired calcium-type chromatographic separation resin from the workshop and wash it with water until the broken resin and sundries are cleaned.

[0015] 2. Hydrochloric acid desalination treatment

[0016] Put the calcium-type chromatographic resin obtained in step 1 into the chromatographic column, rinse with 0.5% hydrochloric acid solution, after the acidity of the inlet and outlet is the same, stop the rinse and soak for 4 hours, then rinse with pure water until neutral.

[0017] 3. Calcium salt regeneration

[0018] Put the calcium type chromatographic separation resin processed in step 2 into the chromatographic separation column, and regenerate it with a concentration of 0.5% calcium chloride solution, control the flow rate of the solution flowing into the chromatographic column to be 30ml / min, and detect it with a pH detector during the regeneration process When the PH value of the effluent liquid is 7.52, stop regeneration and s...

Embodiment 2

[0022] 1. Rinse

[0023] Take 2000g of invalid calcium-type chromatographic separation resin from the workshop and wash it with water. During the washing process, the water flow should be large to wash away the broken resin and sundries.

[0024] 2. Hydrochloric acid desalination treatment

[0025] Put the calcium type chromatographic resin obtained in step 1 into the chromatographic column, rinse with a 5% hydrochloric acid solution, after the acidity of the inlet and outlet is the same, stop the rinse and soak for 4 hours, then rinse with pure water until neutral.

[0026] 3. Calcium salt regeneration

[0027] Put the calcium-type chromatographic separation resin processed in step 2 into the chromatographic separation column, use a concentration of 10% calcium chloride to regenerate, control the flow rate of the solution flowing into the chromatographic column to be 35ml / min, and use a pH detector to detect the outflow during regeneration When the pH value of the liquid is...

Embodiment 3

[0031] 1. Rinse

[0032] Take 1800g of invalid calcium-type chromatographic separation resin from the workshop and wash it with water. During the washing process, the water flow should be large to wash away the broken resin and sundries.

[0033] 2. Hydrochloric acid desalination treatment

[0034] Put the calcium type chromatographic resin obtained in step 1 into the chromatographic column, rinse with 8% hydrochloric acid solution, after the acidity of the inlet and outlet is the same, stop rinsing and soak for 6 hours, then rinse with pure water until neutral.

[0035] 3. Calcium salt regeneration

[0036] Put the calcium type chromatographic separation resin processed in step 2 into the chromatographic separation column, and use a concentration of 13% calcium chloride solution to regenerate, control the flow rate of the solution flowing into the chromatographic column to be 30ml / min, and detect with a pH detector during the regeneration process When the PH value of the ef...

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PUM

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Abstract

The invention discloses a process for regenerating a calcium type chromatographic separation resin, and belongs to the technical field of chemical industry. In the regeneration process, a continuous regeneration method, a stirring regeneration method and an accurate control regeneration terminal technology are utilized. The process specifically comprises the following steps of: washing; desalting by using hydrochloric acid; regenerating, namely treating a calcium type chromatographic resin treated in step 2 by using solution of calcium salt, wherein the principle is that calcium ions in the solution of calcium salt substitute hydrogen ions in the calcium type chromatographic resin to ensure that the calcium type chromatographic resin has separating capacity again; and detecting, namely obtaining the calcium type chromatographic separation resin which meets regeneration requirements through inspection and detection. The soaking regeneration time is short in the regeneration process, the using amount of the acid and the solution of calcium salt can be accurately metered, and the process has the advantages of low pure water consumption, slight acid pollution and the like and the resin can be regenerated completely.

Description

technical field [0001] The invention belongs to the technical field of chemical industry, and in particular relates to a regeneration method of a calcium-type chromatographic separation resin. Background technique [0002] Chromatographic separation resins can separate compounds with little difference in physical and chemical properties, so chromatographic separation resins are increasingly used in pharmaceutical, chemical, and biological industries. [0003] The chromatographic separation resin can regain separation ability through regeneration after failure. At present, the main regeneration process is to rinse the resin with water first, then soak it in hydrochloric acid for a long time, rinse it with pure water, then soak it with calcium salt solution for a long time, and finally rinse it with pure water. During the regeneration process, there are problems such as long immersion regeneration time, inability to accurately measure the amount of acid and calcium salt solut...

Claims

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Application Information

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IPC IPC(8): B01J49/00B01J49/50B01J49/60
Inventor 王成福姜希生杜瑞锋李林张念强
Owner FUTASTE PHARM CO LTD
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