Soil cinnamon leaf extract, its preparation method and its use in treating dyslipidemia
A technology of soil cinnamon leaf and dyslipidemia, applied in the field of soil cinnamon leaf extract
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Embodiment 1
[0024] Embodiment 1 The preparation of soil cinnamon leaf hot water extract of the present invention
[0025] First obtain 950 grams of soil cinnamon leaves that are air-dried and pulverized into powder (powdered), and boil the aforementioned soil cinnamon leaves powder with 15 liters of distilled water for 1 hour to obtain a crude extract (crude) extract). The aforementioned crude extract was collected and filtered through cheesecloth. The filtered filtrate (filtrate) was freeze-dried (lyophilization) to obtain 150 grams of cinnamon leaf hot water extract (hot-water extract) of the present invention. The yield of this example is about 16% (w / dry weight of leaves).
experiment example 1
[0026] Experimental design of experimental example 1 animal model (animal model)
[0027] 40 golden hamsters (Golden Syrian hamster) weighing 100-120 grams were reared in individual plastic cages and maintained in a 12-hour light / dark cycle, 60% humidity and 25°C room temperature. Experimental hamsters were acclimatized for 4 weeks under constant laboratory conditions with ad libitum supply of feed and water before conducting the experiments. Before the experiment, the hamsters were randomly assigned to 5 groups (8 / group), and their body weights were recorded. Then, please refer to the experimental design in Table 1 below. After feeding the aforementioned 5 groups with a normal diet and a high-cholesterol diet (0.2% cholesterol) for 4 weeks, they were then fed the soil cinnamon leaf hot water extract of Example 1 according to the experimental design. Drug or gemfibrozil (gemfibrozil, a known cholesterol-lowering drug) for 5 to 10 weeks, anesthetized with 2% isoflurane inhalat...
experiment example 2
[0031] Experimental example 2 Toxicity analysis of soil cinnamon extract of the present invention
[0032]The present invention uses the mouse model (mouse model) to test the efficacy of the soil cinnamon leaf extract in the treatment of dyslipidemia. Therefore, this experimental example is to monitor the body weight change, liver function and kidney function of the experimental mice to analyze the soil cinnamon leaf extract of the present invention. Whether the substance has adverse effects on the physiology of living animals; Among them, the detection of the aforementioned body weight change can confirm whether the soil cinnamon leaf extract has adverse effects on the physiology of living animals, and secondly, it can standardize follow-up animal experiments to confirm whether the body weight It is one of the physiological variables that the soil cinnamon leaf extract affects mice.
[0033] [weight change]
[0034] Please refer to Table 2 below for the body weight changes o...
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