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Polyene antifungal compositions

A technology of composition and fungi, which is applied in the direction of fungicides, biocides, animal repellents, etc., and can solve the problems of being washed out, reducing the amount of natamycin, and reducing the efficacy of natamycin

Inactive Publication Date: 2012-01-11
DSM IP ASSETS BV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Natamycin may even run off the surface of produce
Second, natamycin may be washed from agricultural products such as plants due to rain or irrigation
Third, there is a risk of drifting, i.e. being less able to be sprayed onto produce without dispersing, resulting in less natamycin reaching the produce
All these disadvantages lead to a reduction in the potency of natamycin and thus to a lack of protection of agricultural products against fungal spoilage

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Effect of thickeners on the antifungal efficacy of natamycin on oranges

[0048] In the experiments, the antifungal activity of antimicrobial compositions comprising natamycin and different thickeners was examined. The thickeners examined were Xanthan Gum, MHEC (Methyl Hydroxyethyl Cellulose, Tylopur MHB3000P), HPMC (hydroxypropyl methylcellulose, Methocel ) and CMC (carboxymethyl cellulose, Blanose ).

[0049] Compositions containing the thickener and the antifungal agent natamycin were prepared as follows. The thickener was dissolved in water by stirring overnight. Then add a suspension containing natamycin to the solution containing the thickener to obtain a composition comprising the thickener at a final concentration of 0.4-0.6% (w / v) and the natamycin at a final concentration of 1000 μg / ml .

[0050] Artificial contamination of fresh untreated oranges. Two spots on the surface area of ​​the peel were damaged on each orange and contaminated with a spore s...

Embodiment 2

[0059] Effect of thickeners on the antifungal efficacy of compositions comprising natamycin and phosphite on oranges

[0060] In this experiment, the antifungal activity of an antimicrobial composition comprising natamycin, phosphite and the above-mentioned thickener was examined as described in Example 1 on oranges stored for 13 days.

[0061] Composition containing at 35mM K 2 CO 3 The final concentration in the buffer was 0.4% (w / v) thickener, 1000 μg / ml natamycin and 240 mM potassium phosphite.

[0062] The results in Table 3 show that, compared with antimicrobial compositions comprising natamycin, sodium phosphite and one of the thickeners xanthan gum, HPMC or CMC, The antimicrobial composition of MHEC better protects oranges against mold growth.

[0063] Table 3: Number of moldy orange wounds after 13 days of storage at room temperature.

[0064] antimicrobial composition

Embodiment 3

[0066] Effect of thickeners on the antifungal efficacy of natamycin on strawberries

[0067]In this experiment, the antifungal activity of an antimicrobial composition comprising natamycin and the above-mentioned thickener was examined on strawberries.

[0068] A composition containing the thickener and the antifungal agent natamycin was prepared as described in Example 1. The composition contained a thickener at a final concentration of 0.6% (w / v) and natamycin at 1000 μg / ml.

[0069] Use 5 μl of freshly prepared spores (10 6 spores / ml) to artificially contaminate fresh, untreated strawberries from local retailers in the Netherlands. Mold spores were prepared using known methods. One hour after contamination, the strawberries were dipped in the freshly prepared antimicrobial composition for 1 minute, dripped and allowed to dry. Experiments were performed in nine replicates. Strawberries were stored for 6 days under the conditions described in Example 1 and mold developme...

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PUM

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Abstract

The present invention relates to polyene antifungal compositions and methods for preparing them. In addition, the invention pertains to the use of the compositions to prevent products from fungal growth.

Description

field of invention [0001] The present invention discloses antimicrobial compositions suitable for preventing fungal diseases on agricultural products such as plants, fruits and vegetables. Background of the invention [0002] It is estimated that about 25% of the world's crop production is lost due to microbial spoilage, of which fungal spoilage is by far the most important cause. The prevention of spoilage in food products is important from an economic as well as a humanitarian point of view. After all, people in many parts of the world are suffering from hunger. [0003] In order to prevent fungal damage to agricultural products such as plants, crops and fruits, fungicides are currently applied, for example by spraying. The currently applied fungicides are associated with several disadvantages. [0004] First, several fungi have developed partial or even complete resistance to certain fungicides due to their frequent use. Therefore, despite extensive treatment with cur...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N43/90A01N25/10A01N25/24A01P3/00
CPCA01N43/90A01N25/10A01N25/24A01N2300/00
Inventor 雅各布斯·斯塔克弗迪南得·桑朵斯·乔则夫·里简·范艾伯特-乔·维斯
Owner DSM IP ASSETS BV
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