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Mass spectrometric nano-spray electrode, manufacturing method and application thereof

A technology of spray electrode and manufacturing method, which is applied in the field of electrodes, can solve the problems of short service life, cumbersome production, instability, etc., and achieve the effects of long service life, improved sensitivity of mass spectrometry, and simple production

Inactive Publication Date: 2013-12-04
SHANGHAI INST OF ORGANIC CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] In order to solve the problems of short service life, instability, cumbersome manufacture and high cost of the existing mass spectrometer nanospray electrode, the present invention provides a device with good stability, high sensitivity, good reproducibility of mass spectrometry results and long service life. Mass spectrometer nanospray electrode and its preparation method and application

Method used

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  • Mass spectrometric nano-spray electrode, manufacturing method and application thereof
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  • Mass spectrometric nano-spray electrode, manufacturing method and application thereof

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Embodiment

[0055] One, make the mass spectrometer nanospray electrode of the present invention

[0056] a) The fused silica capillary is first pretreated with an aqueous sodium hydroxide solution with a concentration of 0.5mol / L, then rinsed with water and acetone, and blown dry with nitrogen for use; the purpose of this treatment is to increase the silanol on the surface of the fused silica capillary;

[0057] b) adding carbon nanotubes into concentrated nitric acid with a concentration of 65% to 68% by mass of nitric acid, ultrasonically oscillating to disperse it evenly, and then heating and refluxing at 110°C to 120°C for 5 to 8 hours; The purpose of the oxidation treatment is to increase the hydroxyl and carboxyl groups on the surface of the carbon nanotubes, improve the solvophilicity of the carbon nanotubes, and be more conducive to the dispersion in the sol;

[0058] c) Add 1.2 mg of the treated carbon nanotubes to a mixed silane solution of 400 μL γ-aminopropyltrimethoxysilane a...

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Abstract

The invention discloses a mass spectrometric nano-spray electrode, a manufacturing method and the application thereof. The mass spectrometric nano-spray electrode is composed of a fused quartz capillary tube and a CNT (carbon nanotube) doped sol-gel composite material, wherein the CNT doped sol-gel composite material is coated on an outlet end of the capillary tube. The method for manufacturing the electrode comprises the following steps: firstly, carrying out pretreatment on the used fused quartz capillary tube and the CNT; then, preparing sol doped with the CNT; and finally, coating the outlet end of the fused quartz capillary tube with the sol, and carrying out solvent volatilizing and aging. The mass spectrometric nano-spray electrode disclosed by the invention has the advantages of good stability, high sensitivity, long service life, high reusability, simpleness for manufacturing, low cost, and capability of continuously realizing nano-spray for 52 hours and continuously being used 170 hours, and the like and can be continuously used for 170 hours, and the mass spectrometric results have good reproducibility; and the mass spectrometric nano-spray electrode can be used in CE (capillary electrophoresis) or capillary LCMS (liquid chromatography-mass spectrometry) analysis technique, and also can be used in a nano-spray mass spectrographic analysis technique.

Description

technical field [0001] The present invention relates to a mass spectrometer nanospray electrode and its manufacturing method and application, specifically, to a mass spectrometer nanospray electrode based on carbon nanotube doped sol-gel conductive coating and its manufacturing method and application, belonging to the electrode technology field. Background technique [0002] Electrospray ionization technology applies high voltage (1-5KV) to charged droplets to generate spray, which greatly facilitates the combination of mass spectrometry and various liquid phase separation techniques. Wilm and Mann further developed this technology and proposed the concept of "nano-level flow rate electrospray" (referred to as "nanospray"). Decrease the mass spectrometer injection flow rate from 10 μL / min to 1 mL / min to nanoliters per minute. As the flow rate decreases, the efficiency of nanospray ionization is greatly improved; a stable spray can be generated without sheath gas or heating...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): H01J49/16H01J9/02G01N27/62
Inventor 康经武张含智
Owner SHANGHAI INST OF ORGANIC CHEM CHINESE ACAD OF SCI
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