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Quetiapine fumarate sustained-release tablets and preparation method thereof

A technology of quetiapine fumarate and quinolone fumarate, which is applied in the field of quetiapine fumarate sustained-release tablets and its preparation, can solve problems such as environmental and human hazards and irritations, and complex preparation processes, and achieve Good sustained release performance, simple process effect

Inactive Publication Date: 2013-03-27
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the waxy material cetyl alcohol used in the above-mentioned patents is harmful and irritating to the environment and the human body, and the preparation process is relatively complicated.

Method used

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  • Quetiapine fumarate sustained-release tablets and preparation method thereof
  • Quetiapine fumarate sustained-release tablets and preparation method thereof
  • Quetiapine fumarate sustained-release tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032]Embodiment 1: Preparation of quetiapine fumarate sustained release tablet

[0033] Get 200g of quetiapine fumarate (calculated as quetiapine) to pulverize, pass through an 80-mesh sieve, mix with 58g of acrylic resin RL PO, and use 9g of 10% polyvinylpyrrolidone K-30 as a binder to make a soft material; Granulate with 18-mesh sieve, dry, granulate with 18-mesh sieve, add 3g of magnesium stearate, mix well, and tablet.

Embodiment 2

[0034] Embodiment 2: Preparation of quetiapine fumarate sustained release tablet

[0035] Get 200g of quetiapine fumarate (calculated as quetiapine) to pulverize, pass through an 80-mesh sieve, mix with 58g of acrylic resin RS PO, and use 9g of 10% polyvinylpyrrolidone K-30 as a binder to make a soft material; Granulate with 18-mesh sieve, dry, granulate with 18-mesh sieve, add 3g of magnesium stearate, mix well, and tablet.

Embodiment 3

[0036] Embodiment 3: Preparation of quetiapine fumarate sustained-release tablet

[0037] Take 200g of quetiapine fumarate (calculated as quetiapine) and pulverize, pass through an 80-mesh sieve, mix with 29g of acrylic resin RL PO, 29g of acrylic resin RS PO, and use 9g of 10% polyvinylpyrrolidone K-30 as a bond Prepare soft material; pass through 18-mesh sieve to granulate, dry, granulate with 18-mesh sieve, add 3g of magnesium stearate, mix well, and press into tablets.

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Abstract

The invention belongs to the field of medicinal preparations, and discloses quetiapine fumarate sustained-release tablets and a preparation method thereof. The sustained-release tablets are mainly prepared from the following raw materials in part by mass: 1 part of quetiapine fumarate (based on quetiapine), 0.1 to 1 part of acrylic resin framework material, 0 to 0.5 part of filling agent, 0.04 to 0.05 part of adhesive and 0.01 to 0.02 part of lubricating agent. The sustained-release tablets can comprise hydrophilic gel framework material for adjusting the release rate of the main medicament, and the mass ratio of the quetiapine to the hydrophilic gel framework material is 1: (0.1-0.5). The prepared quetiapine fumarate sustained-release tablets can be used for treating schizophrenia. The sustained-release tablets have the advantages of reducing the administration frequency, improving the administration compliance of a patient, improving the medicinal effect, ensuring application safety and the like, and are more suitable for patients. Meanwhile, the preparation method of the sustained-release tablets is simple and favorable for industrialized large-scale production.

Description

technical field [0001] The invention relates to a pharmaceutical preparation and a preparation method thereof, in particular to a quetiapine fumarate sustained-release tablet and a preparation method thereof. Background technique [0002] Schizophrenia is a psychiatric disease, a persistent, usually chronic, major mental illness, and the most serious of all mental illnesses, characterized by splits in basic personality, thinking, emotion, and behavior, and differences in mental activity and the environment. Coordination is the most common type of mental illness, and it usually occurs in young and middle-aged adults, which in turn affects behavior and emotion. Its etiology has not been fully elucidated. The course of schizophrenia is often protracted and develops progressively. If it is found early, it should be given reasonable treatment as soon as possible. The prognosis of most patients is relatively optimistic. A small number of patients are delayed due to untimely and u...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/22A61K31/554A61K47/32A61K47/38A61P25/18
Inventor 曹青日刘妍崔京浩
Owner SUZHOU UNIV
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