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Extract of rust-coloured crotalaria herb with root for treating cardiovascular disease, and preparation method and application thereof

A technology of bellflower extract and cardiovascular and cerebrovascular diseases, which is applied in traditional Chinese medicine extracts and in the field of pharmacy, can solve problems such as the limitation of side effects of blood lipid-lowering drugs, achieve prevention and treatment of cardiovascular diseases, reduce environmental pollution, and improve Effect of Lipid Levels

Inactive Publication Date: 2012-02-01
重庆化工职业学院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most clinical methods for lowering blood cholesterol levels require strict diet control and rely on drugs, and the side effects of blood lipid-lowering drugs limit their application to a certain extent

Method used

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  • Extract of rust-coloured crotalaria herb with root for treating cardiovascular disease, and preparation method and application thereof
  • Extract of rust-coloured crotalaria herb with root for treating cardiovascular disease, and preparation method and application thereof
  • Extract of rust-coloured crotalaria herb with root for treating cardiovascular disease, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1 Preparation of Bellflower Extract for the Treatment of Cardiovascular and Cerebrovascular Diseases

[0017] Weigh 5.0kg of bell prairie herbs, crush them, infiltrate with 1L of 90% ethanol solvent, install a percolation column, add solvent to soak for 12 hours, and start percolation. The percolation volume is 8-10 times the volume of the medicinal materials. The amount of sterol is the judgment basis of the percolation volume, and the percolation filtrate is obtained;

[0018] For the selection of percolation solvent, 60-95% can be selected, and the solvent in this range can realize the extraction of effective parts in Bellflower; but the optimal solvent concentration is 75-90% ethanol;

[0019] Combine the percolation filtrates, recover the ethanol in the ethanol extract under reduced pressure, until there is no alcohol smell, add water continuously during the process of recovering the ethanol, so that the precipitated substances in the process of recovering...

Embodiment 2

[0028] Example 2 Experimental study on the hypolipidemic effect of bellflower extract on hyperlipidemia model rats

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Abstract

The invention provides an extract of rust-coloured crotalaria herb with root for treating cardiovascular disease, and a preparation method and application thereof. The extract of rust-coloured crotalaria herb with root comprises sterides and oleanolic acid which can effectively improve lipid levels of mice suffering from hyperlipemia, reduce serum total cholesterol, and low density lipoprotein cholesterin, and prevent and treat cardiovascular disease; and the preparation method for the extract is simple, slightly pollutes environment and is suitable for large-scale industrial production.

Description

technical field [0001] The present invention relates to a traditional Chinese medicine extract and its application in the field of pharmacy, and more specifically relates to a bellflower extract for treating cardiovascular and cerebrovascular diseases, its preparation method and application. technical background [0002] Epidemiological studies have shown that dyslipidemia is an extremely important risk factor for atherosclerosis. In the past, the levels of atherosclerotic cholesterol and triglycerides in the blood of Chinese people were lower than those of Westerners, while the level of high-density lipoprotein cholesterol with anti-atherosclerotic effects was higher, which was considered to be the cause of atherosclerosis and atherosclerosis. Coronary atherosclerotic heart disease (CHD) is one of the leading causes of less. However, in recent years, the investigation of the blood lipid levels of healthy people in my country found that the blood total cholesterol and trigl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/48A61P9/00
Inventor 杨宪刘筱琴唐倩高小丽王黎贺小兰张雪池雨芮揭芳芳
Owner 重庆化工职业学院
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