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Compound pharmaceutical composition containing midazolam and neuro protective agent

A neuroprotective agent, midazolam technology, applied in the field of medicine, can solve problems such as foaming at the mouth, inability to achieve epileptic seizures in a timely manner, and inconvenient use of suppositories

Active Publication Date: 2012-02-01
INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Existing emergency drugs for epilepsy, such as midazolam, have various dosage forms, such as oral film, suppository, injection, etc., but the effect is not satisfactory
Injections require professional medical personnel to inject, which cannot achieve the purpose of timely drug delivery for epileptic seizures, and is inconvenient to use
Oral film preparations are inconvenient to use due to disturbance of consciousness, trismus, and even foaming at the mouth during most epileptic seizures, which affect the speed of administration and the effect of use.
In addition, most of the current treatment of epilepsy is to first rescue the patient from the state of epileptic seizures, and then take protective measures for the cranial nerves. If the patient's cerebral nerves are not protected in time, patients with recurrent epileptic seizures will have symptoms of cranial nerve dysfunction.

Method used

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  • Compound pharmaceutical composition containing midazolam and neuro protective agent
  • Compound pharmaceutical composition containing midazolam and neuro protective agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0084] Prescription of compound nasal spray preparation of midazolam and neuroprotective agent:

[0085]

[0086] Preparation method: a. Add the prescribed amount of main drug midazolam into the prescribed amount of solubilizer, and stir for 5 minutes. b. Add the prescribed amount of pH regulator and stir in a 60°C water bath for 10 minutes. c. Add neuroprotective agent VB12 and appropriate amount of flavoring agent sequentially, sterilize and pot, and obtain.

[0087] The compound nasal spray preparation of midazolam and neuroprotective agent provided in Example 1 of the present invention is a red clear solution, the pH value of the solution is about 4, and the method of use is to make the patient lie on the back and lean back about 15 ° Spray the patient's two nostrils with nasal spray preparation, pinch the nose 3-5 times, the operation is convenient and quick.

Embodiment 2

[0089] Prescription of compound nasal spray preparation of midazolam and neuroprotective agent:

[0090]

[0091] Preparation method: a. Add the prescribed amount of main drug midazolam into the prescribed amount of solubilizer, and stir for 5 minutes. b. Add the prescribed amount of pH adjuster, stir in a water bath at 60°C for 10 minutes c. Add neuroprotective agent VB12 and appropriate amount of flavoring agent in sequence, sterilize and seal, and the product is ready.

[0092] The compound nasal spray preparation of midazolam and neuroprotective agent provided in Example 2 of the present invention is a red clear solution, and the pH value of the solution is about 4. ° Spray the patient's two nostrils with nasal spray preparation, pinch the nose 3-5 times, the operation is convenient and quick.

Embodiment 3

[0093] The pharmacokinetics of the compound nasal spray preparation of embodiment 3 midazolam and neuroprotective agent

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PUM

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Abstract

The invention relates to a compound pharmaceutical composition containing midazolam and a neuro protective agent and particularly relates to a pharmaceutical composition. The compound medicament composition provided by the invention comprises an effective amount of midazolam or pharmaceutically acceptable salt thereof for treatment and / or prevention, the neuro protective agent and an optional andpharmaceutically acceptable carrier. The invention also relates to an application of a combination of midazolam or the pharmaceutically acceptable salt thereof and the neuro protective agent in the aspect of preparing medicaments for resisting anxiety, sedating and hypnotizing, resisting convulsion, resisting epilepsy and treating central muscular flaccidity and the like. The invention further relates to a method for preparing the pharmaceutical composition. By virtue of combining midazolam with the neuro protective agent such as vitamin B12, not only can the medical effect of midazolam be effectively exerted, but also cerebral nerve functions can be protected, and the pharmaceutical composition can be conveniently administrated and can take effect rapidly.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a compound pharmaceutical composition comprising midazolam and a neuroprotective agent which can be used as a sedative-hypnotics, in particular to a nasal administration preparation comprising midazolam and a neuroprotective agent. Background technique [0002] Midazolam is a central nervous system depressant that has anxiolytic, sedative-hypnotic, anticonvulsant, antiepileptic, and central muscle relaxant effects. Clinically, it is mainly used for the treatment of febrile convulsions, epilepsy, insomnia, anxiety in children and the preoperative administration of endoscopy. [0003] It is well known that recurrent seizures, epilepsy and other diseases will adversely affect the function of the cranial nerves, and even damage the normal function of the cranial nerves. [0004] Existing drugs for emergency treatment of epilepsy, such as midazolam, have various dosage forms, such as ...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61K31/5517A61K31/714A61P25/08A61P25/20A61P25/22A61K31/4152
Inventor 郑爱萍崔旭毕芸祺张晓燕孙建绪
Owner INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
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