Crystallizing tank used for vincamine

Abstract

The invention relates to a crystallizing tank used for vincamine, comprising a tank rack, a tank and a stirring device, wherein the tank and the stirring device are arranged on the tank rack; the tank comprises a tank body and a tank cover connected with the tank body in a sealing mode; the bottom of the tank body is provided with a discharge hole; a dump valve is arranged on the discharge hole; the tank cover is provided with a feeding hole; the circumstance of the tank body is also provided with a jacket with a cooling water inlet and a cooling water outlet; and the discharge valve comprises a valve plate and a filter plate for blocking the discharge hole. Especially, the thickness of the discharge hole is same with that of the bottom of the tank body; and the valve plate is used for blocking an annular continuous arc-shaped surface formed by parts of upper surface of the discharge hole and the inner surface of the bottom of the tank. The crystallizing tank is characterized in that the valve plate of the discharge valve is used for blocking the annular continuous arc-shaped surface formed by parts of upper surface of the discharge hole and the inner surface of the bottom of the tank without any stirring dead corner, and fine-grain crystallization with even particle diameter can be obtained.

Description

technical field [0001] The invention relates to a crystallization tank, in particular to a crystallization tank for vincamine. Background technique [0002] Vincamine is an alkaloid with a ivoryne structure and has strong physiological activity. Early foreign studies focused on its hypotensive activity. Because it can penetrate the blood-brain barrier, it was later found that it has a good effect on dilating blood vessels and increasing cerebral blood flow, but has no effect on the heart, blood vessels, and blood pressure. It is currently the first-line drug for the treatment of cerebral ischemia, and its clinical indications include cerebrovascular disorders, cerebral embolism, cerebral thrombosis, and hemorrhagic sequelae. The curative effect on cerebral arteriosclerosis is stronger than hydroergot and papaverine. At present, vincamine can be prepared by semi-synthetic process, for example, Chinese invention patent publication CN 102108082A discloses a method for prepari...

AI Technical Summary

Problems solved by technology

Another feature of the existing crystallization tank is that it has an extension section downward from the discharge port, and in fact a discharge channel has been formed at the discharge port, and at least part of the gate plate of the discharge valve will The lower end of the channel is blocked, and such a discharge channel inevitably constitutes a dead angle of stirring. For a product such as vincamine, which crystallization itself is prone to agglomeration, such a dead angle of stirring directly leads to large crystals in the crystalline product. block, and can not get uniform fine-grained crystals, seriously affecting the quality of the product

Images