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Micro-reactor using surface acoustic wave as energy source and reaction method thereof

A surface acoustic wave and microreactor technology, applied in chemical instruments and methods, chemical/physical/physicochemical processes of applied energy, laboratory containers, etc., can solve the problem of limiting the application of microreactors and the inability to realize Heating and other issues can be avoided to avoid oil phase pollution, simple structure and avoid evaporation

Inactive Publication Date: 2014-01-22
NINGBO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The microreactor can effectively reduce the evaporation of the reactants, but cannot realize the heating of the reactants, thus limiting the application of the microreactor

Method used

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  • Micro-reactor using surface acoustic wave as energy source and reaction method thereof
  • Micro-reactor using surface acoustic wave as energy source and reaction method thereof

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Effect test

Embodiment 1

[0026] A kind of microreactor with surface acoustic wave as energy source that the present invention proposes, such as figure 1 and figure 2As shown, it mainly includes a signal generating device 1 and a piezoelectric substrate 2, the upper surface of the piezoelectric substrate 2 is a working surface, and the working surface of the piezoelectric substrate 2 is photoetched with two An interdigital transducer 3 for exciting the surface acoustic wave and two reflective gratings 4 for reflecting the surface acoustic wave excited by the interdigital transducer 3 to reduce the power of the RF signal, the two interdigital transducers 3 It has the same size and is located on both sides of the symmetrical edge regions of the working surface of the piezoelectric substrate 2, and is arranged on the working surface of the piezoelectric substrate 2 and on the acoustic transmission path of the surface acoustic waves excited by the two interdigital transducers 3 There is a hydrophobic lay...

Embodiment 2

[0036] A kind of reaction method that utilizes the microreactor described in embodiment one to carry out biochemical reaction with surface acoustic wave as energy source, it mainly comprises the following steps:

[0037] ①The bottom of the PDMS microgroove with top opening and bottom opening is closely connected with the hydrophobic layer set on the working surface of the piezoelectric substrate, and ensure that the PDMS microgroove is located at the surface acoustic wave excited by the two interdigital transducers. On the acoustic transmission path, place a PDMS fixed sheet with a metal micro-pool on the top of the PDMS micro-groove that has been injected with glycerol microfluid, so that the metal micro-pool is suspended in the PDMS micro-groove, and then connect the signal generator, power amplifier and interdigital transducers. In the actual operation process, the injection amount of the glycerol microfluid is preferably after the metal microcell is suspended in the PDMS m...

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Abstract

The invention discloses a micro-reactor using surface acoustic wave as energy source and a reaction method thereof. A micro heating unit is arranged on a hydrophobic layer arranged on a working surface of a piezoelectric substrate and comprises a PDMS microgroove for containing glycerin microfluid and metal microgroove for containing micro-reactant waiting for reaction. Bottom of the PDMS microgroove is clung to the hydrophobic layer, and the metal microgroove is suspended in the PDMS microgroove by a PDMS stator. So surface acoustic wave excitated by an interdigital transducer arranged on the working surface of the piezoelectric substrate radiates the glycerin microfluid in the PDMS microgroove to heat the glycerin microfluid, so as to carry out biochemical reaction on the micro-reactant in the metal microgroove by the metal microgroove with good thermal conductivity. The invention utilizes surface acoustic wave excitated by the interdigital transducer and glycerin microfluid in the PDMS microgroove to realize biochemical reaction, which needs to be conducted at a temperature higher than a room temperature, and greatly expand scope of application of a micro fluidic chip.

Description

technical field [0001] The invention relates to a microreactor in a microfluidic chip, in particular to a microreactor using surface acoustic waves as an energy source and a reaction method thereof. Background technique [0002] A microfluidic chip is a microanalysis system that integrates sample pretreatment, mixing, reaction, separation, and detection into one or more chips to replace traditional laboratory work. The microfluidic chip has the advantages of less sample consumption, simple operation, accurate completion of the whole process from sample preparation to result display in a short period of time, and the ability to effectively overcome experimental errors caused by manual operations in traditional laboratory work. Many advantages, such as microfluidics, have attracted great attention from experts in the field of microfluidics at home and abroad, and have increasingly become an international frontier research hotspot, and have been used in chemical analysis, DNA ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J19/00B01J19/10B01L3/00
Inventor 章安良韩庆江尉一卿张悦高挺胡楚黄昶黄孝圣
Owner NINGBO UNIV