Yixuanning capsule, its identification and content determining method

Abstract

The invention relates to a traditional Chinese medicinal preparation, i.e. a Yixuanning capsule, and its identification and content determining method. The identification method is to place the Yixuanning capsule under a microscope for observation so as to observe irregular black lumps with jagged edges and orange-yellow or blue luster. The content determination method employs high performance liquid chromatography (HPLC). Specifically, 5 microliters of a reference solution and 5 microliters of a sample solution are respectively adsorbed accurately and injected into a liquid chromatograph for determination, thus obtaining the content. Each Yixuanning capsule of the invention contains at least 0.5mg of scutellaria in Baicalin (C21H18O11) terms. In the invention, a specificity test of dried orange peels is reserved, thin layer chromatography identification of white peony roots is modified and improved, thin layer chromatography identification of chrysanthemums and Chinese wolfberries is newly added, and simultaneously content determination of Baicalin is modified and improved. By means of parameter test screening, the invention establishes a sensitive, specific and reliable content determining method, which can has the characteristics of strong specificity, high accuracy and easy control, so that the product quality of the capsule in the invention can be effectively improved and the curative effects of the product can be guaranteed.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation, namely Yixuanning capsule and its identification and content determination method. Background technique [0002] In the prior art, Yixuanning Capsules are recorded in "National Drug Administration Drug Standards (Revised) Promulgation Document 2002ZFB0282". Yixuanning Capsule consists of 20g cocklebur (fried), 15g chrysanthemum, 15g dannanxing, 15g baicalin, 15g bamboo, 20g oyster (calcined), 10g hawthorn, 15g tangerine peel, 15g white peony root, 15g pig iron powder, 20g poria cocos, Lycium barbarum 20g. Preparation method: For the above twelve flavors, add pig iron and oysters with appropriate amount of water, first decoct for 2 hours, then add cocklebur (stir-fried), chrysanthemum, Dannanxing, Zhuru, tangerine peel, and continue decocting for three times (1, 1, 1.5 hours), filter in stages, combine the filtrates, concentrate to a clear paste with a relative density of 1.0-1.2 (80...

AI Technical Summary

Problems solved by technology

Usage and Dosage: Take orally, 4-6 capsules at a time, 3 times a day. The disadvantage is that there are few identification items in the original quality standard, which is not conducive to the production process control and product quality monitoring of Yixuanning Capsules, and the drug effect is low. It is difficult to guarantee, and the safety hazard of patients' medication is relatively large