Bio-absorbable medical compound material and preparation method thereof

A composite material and biological technology, applied in the fields of bone trauma surgery, bone defect repair surgery, biomedical equipment, plastic and cosmetic medical equipment, can solve the problem of reducing the ability of fracture fixation, affecting imaging examination, chemotherapy of tumor patients, non-degradable absorption, etc. problems, to achieve the effect of improving strength and toughness, controllable degradation and absorption speed, and overcoming too high and too strong acidity

Inactive Publication Date: 2012-04-04
SOUTHEAST UNIV
View PDF3 Cites 29 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Internal bone fixation is a routine method in orthopedic trauma surgery, bone defect repair surgery, and plastic surgery. Currently, internal fixation plates and screws are most commonly made of pure titanium or titanium alloy, which have stable fixation effects and superior biocompatibility. It provides a good internal environment for bone tissue healing, but it also has the following problems: (1) The elastic modulus of titanium metal is 8 times that of cortical bone, and it has a stress shielding effect on normal bone tissue, which is easy to cause osteoporosis and relapse Fracture; (2) It cannot be degraded and absorbed. If it is used for a long time, it will block X-rays and affect imaging examinations and chemotherapy for cancer patients.
[0006] However, the corrosion resistance of magnesium alloys is poor, and the biodegradation rate in the human body is too fast, and the corrosion is often serious before the fracture fixation and healing are not completely stable, and the exces

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Bio-absorbable medical compound material and preparation method thereof
  • Bio-absorbable medical compound material and preparation method thereof
  • Bio-absorbable medical compound material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0033] The preparation method of the bioabsorbable medical composite material is as follows: selecting a magnesium alloy wire or fiber with a suitable length and diameter as a reinforcing phase, weighing the corresponding weight of the magnesium alloy wire (or fiber) and polylactic acid according to the formula, Prepare a ceramic protective film on the surface of magnesium alloy wire (or fiber) by micro-arc oxidation method, and according to the arrangement and distribution requirements of the reinforcement phase in the matrix, the magnesium alloy wire or fiber with a ceramic protective layer on the surface is first oriented with a mold The arrangement is fixed, or the magnesium alloy wire or fiber is artificially woven into a two-dimensional grid or a three-dimensional tube grid, and fixed with a mold; secondly, the polylactic acid powder is directly mixed with the magnesium alloy wire or fiber until it is evenly prepared, and then The mixture is molded or extruded at 80°C to ...

Embodiment 1

[0038] Seventeen AZ31B magnesium alloy wires with a diameter of 0.32mm and a length of 80mm were selected as the reinforcing phase, and 10g / L sodium silicate, 2g / L NaOH and 10g / L hydroxyapatite nanoparticles were used as the micro-arc oxidation electrolyte system. Magnesium alloy wire is immersed in it, 400V voltage is applied, and micro-arc oxidation treatment is carried out for 10 minutes, so that a layer of ceramic protective film rich in magnesium oxide, magnesium silicate and hydroxyapatite is formed on the surface in situ. Fix the reinforcing phase through two ends as follows figure 1 The orientation shown in the schematic diagram is arranged in the cavity of a 70mmxφ5mm mold. Weigh 1.7g of polylactic acid with a molecular weight of 200,000, heat it to 200°C to melt, then inject the solution into the mold cavity, mix the polylactic acid solution and magnesium alloy wire evenly, and mold it into a rod at 190°C. Finally, it is processed into orthopedic fixation devices su...

Embodiment 2

[0040] Select 10 MB8 magnesium alloy wires with a length of φ0.8mm and a length of 80mm as the reinforcing phase, and pass it through the micro-arc oxidation treatment method as shown in Example 1 to obtain a film layer rich in magnesium oxide, magnesium silicate, and hydroxyapatite . The magnesium alloy wire after micro-arc oxidation is fixed at both ends, arranged and fixed along the length direction of the mold cavity with a specification of 5mmx20mmx70mm, such as figure 2 As shown, the distance between the wires should be more than 1mm; take 8.7g of polylactic acid with a molecular weight of 200,000, heat it to 200°C and melt it, then inject the solution into the mold cavity, and mix the polylactic acid solution with the magnesium alloy wire. Uniform, molded at 190°C. Finally, it is processed into orthopedic fixation devices such as bone plates by ordinary machining methods.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Diameteraaaaaaaaaa
Lengthaaaaaaaaaa
Outer diameteraaaaaaaaaa
Login to view more

Abstract

The invention discloses a bio-absorbable medical compound material and a preparation method thereof. In the invention, an absorbable high polymer material is taken as a substrate, and an oriented and dispersed array is formed in the substrate through magnesium alloy wires or fibers which are subjected to micro-arc oxidation, or a two-dimensional latticed structure or a three-dimensional latticed structure is formed by weaving the magnesium alloy wires or fibers in the substrate for enhancing the mechanical performance of the absorbable compound material; degradable polymer substrates such as polylactic acid and the like are mixed with the wild phases of the magnesium alloy wires or fibers, are molded or extruded into bars or plates under certain pressures, and are treated with subsequent machining, so that various degradable biological medical compound materials can be obtained. The method has the characteristics of mild processing condition and easiness for operating; the product has high mechanical performance, high biocompatibility and wide application prospect, and is suitable for orthopedic internal fixation products of various shapes; the production degradation is safe, stable and controllable; and the pain to a patient caused by secondary operation or advanced invalidation of the conventional orthopedic product is avoided.

Description

technical field [0001] The invention relates to an orthopedic internal fixation material in medical equipment, belongs to the field of biomedical equipment, and is particularly suitable for the fields of orthopedic trauma surgery, bone defect repair surgery, and medical equipment for plastic surgery. Specifically, it is a bioabsorbable medical composite material, which is a bone internal fixation composite material formed by compounding absorbable magnesium alloy wire or fiber reinforcement phase and polylactic acid matrix. Background technique [0002] Internal bone fixation is a routine method in orthopedic trauma surgery, bone defect repair surgery, and plastic surgery. Currently, internal fixation plates and screws are most commonly made of pure titanium or titanium alloy, which have stable fixation effects and superior biocompatibility. It provides a good internal environment for bone tissue healing, but it also has the following problems: (1) The elastic modulus of tit...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61L31/12A61L31/06A61L31/14
Inventor 储成林薛烽韩啸董寅生白晶郭超盛晓波王世栋
Owner SOUTHEAST UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap