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Medical application of GHGKHKNK octopeptide with anti-tumor synergetic effect on 5-fluorouracil

A technology of fluorouracil and synergistic effect is applied in the field of preparing medicines for the anti-tumor synergistic effect of 5-fluorouracil, which can solve the problems of fast metabolism, short half-life, bone marrow suppression in patients and hemorrhagic enteritis, and achieves good effect.

Inactive Publication Date: 2012-04-11
BEIHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

5-Fu has a broad anti-tumor spectrum, but it metabolizes quickly in the body, has a short half-life, and has severe toxic reactions, which can cause myelosuppression and hemorrhagic enteritis in patients.

Method used

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  • Medical application of GHGKHKNK octopeptide with anti-tumor synergetic effect on 5-fluorouracil
  • Medical application of GHGKHKNK octopeptide with anti-tumor synergetic effect on 5-fluorouracil
  • Medical application of GHGKHKNK octopeptide with anti-tumor synergetic effect on 5-fluorouracil

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Embodiment Construction

[0015] According to the known methods in the pharmaceutical industry, the GHGKHKNK octapeptide is used as a drug for the joint synergistic effect of 5-Fu, mixed with one or more pharmaceutically acceptable carriers or excipients, and can be made into various Pharmaceutical composition in dosage form. Including oral medicaments or injection medicaments, the oral medicaments can be drop pills, soft capsules or freeze-dried powder injections, etc., the injection medicaments can be injection emulsions, etc., and the injection emulsions can be intravenous injection emulsions and intramuscular injection emulsions , Emulsion for intraperitoneal injection or emulsion for subcutaneous injection, etc.

[0016] The following experimental example further illustrates the present invention through the anti-cancer pharmacological effect experiment of GHGKHKNK octapeptide combined with 5-Fu, but it does not mean that the present invention is limited to this example.

[0017] Following experi...

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Abstract

The invention discloses application of GHGKHKNK octopeptide in preparation of medicaments with an anti-tumor synergetic effect on 5-fluorouracil and provides an synergetic effect of GHGKHKNK octopeptide on anti-cancer medicaments. The GHGKHKNK octopeptide can achieve a better effect when being used together with 5-Fu; and the GHGKHKNK octopeptide can be used for enhancing the anti-cancer effect of 5-Fu and simultaneously obviously reducing the toxic and side effects of 5-Fu, thereby providing a better method for treating cancers.

Description

technical field [0001] The invention relates to the synergistic effect of GHGKHKNK octapeptide on anticancer drugs, in particular discloses the use of GHGKHKNK octapeptide in the preparation of drugs with antitumor synergistic effect on 5-fluorouracil, and belongs to the technical field of medical pharmacy. Background technique [0002] At present, cancer has become one of the main diseases causing human death. According to the World Health Organization, more than 10 million new cancer cases occur in the world every year. At present, the main methods for treating cancer include: surgical treatment, chemotherapy of anticancer drugs, radiotherapy, biological response modifiers and other treatments. However, the selectivity of anticancer drugs is poor, and the toxicity and side effects are large, so the use in cancer treatment is limited. For example: 5-fluorouracil (5-fluorouracil, referred to as: 5-Fu) is one of the most widely used anticancer drugs in the world, and it is ...

Claims

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Application Information

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IPC IPC(8): A61K38/08A61P35/00
Inventor 杜培革韩笑安丽萍李娜徐广宇姜爽詹巾卓孙汇王拓李坦诚
Owner BEIHUA UNIV