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Method for detecting high molecular weight substance in traditional Chinese medicine injection

A high-molecular-weight, injection-based technology, applied in measuring devices, material separation, and analysis of materials, can solve unexplainable problems and achieve the effects of increasing convenience, saving clinical emergency time, and reducing medication pain

Inactive Publication Date: 2012-04-11
张恒
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Problems solved by technology

However, the skin test can only predict the immediate type I allergic reaction, and the positive coincidence rate is only 30%. Even if the skin test is negative, it cannot explain that no allergic reaction will occur in the future, which cannot be predicted by the skin test.

Method used

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  • Method for detecting high molecular weight substance in traditional Chinese medicine injection

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Embodiment 1

[0013] Embodiment 1: a kind of method for detecting high-molecular-weight substances in Chinese medicine injection, the method comprises the following steps: a, preparation of contrast solution: get ribonuclease A, human insulin, thymosin α, human growth hormone release inhibitory factor 4 kinds Each 1ml of the solution is placed in a 25ml volumetric flask, diluted with water and fixed to the mark; then 2.5ml of the solution in each of the above-mentioned volumetric flasks is taken, and the volume is adjusted to 25ml with the volumetric flask respectively to obtain a contrast solution; b, the volume of the test solution Preparation: Get 20ml of the test product Chinese medicine injection and add it into an ultrafiltration centrifuge tube, centrifuge at 6000r / min for 10min, get the residue and settle to 1ml to get the test solution; c, detection: draw the test solution precisely Inject the high-performance liquid chromatograph with contrast solution, measure the chromatogram of ...

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Abstract

The invention relates to a method for detecting high molecular weight substances in the traditional Chinese medicine injection, which comprises the steps of: reference solution preparation: taking solution, adding water for dilution and fixing the volume to a scale to obtain the reference solution; test sample solution preparation: taking test sample traditional Chinese injection, adding into an ultrafiltration centrifugal tube for centrifugation, taking residues and fixing the volume to obtain the test sample solution; and detection: respectively and precisely absorbing the test sample solution and the reference solution, filling into a high-efficiency liquid chromatograph, determining according to high-efficiency liquid chromatography, recording a test sample solution chromatogram and a reference solution chromatogram, determining the content of substances with molecular weight being larger than the molecular weight of the reference solution as the content of the high molecular weight substances in the traditional Chinese medicine injection and finally measuring the lowest detection limit. The method provided by the invention can be used for detecting the high molecular weight substances in the traditional Chinese medicine injection production, can effectively monitor the probably dragged-in high molecular weight substances and is of great importance.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine detection, and in particular relates to a method for detecting high molecular weight substances in traditional Chinese medicine injections. Background technique [0002] For traditional Chinese medicine injection products containing high molecular weight substances, from the perspective of safety, patients need to undergo skin tests when applying them. However, the skin test can only predict immediate type I hypersensitivity reactions, and the positive coincidence rate is only 30%. Even if the skin test is negative, it cannot explain that no allergic reaction will occur in the future, which is unpredictable by the skin test. Therefore, in order to ensure the safety and effectiveness of clinical medication, the content of high-molecular-weight substances in traditional Chinese medicine injection products is detected, and the high-molecular-weight substances that may be brought ...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/36
Inventor 张恒
Owner 张恒
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