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Method for increasing endogenous plasmalogen levels in mammals

A plasmalogen, mammalian technology, used in the field of alkylglycerols and alkoxyglycerols, capable of addressing diseases and disorders, adverse animal health, reducing

Inactive Publication Date: 2012-04-11
NESTEC SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Similarly, endogenous plasmalogen levels are known to decrease as animals age, leading to the development of diseases and conditions that are detrimental to the animal's health

Method used

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  • Method for increasing endogenous plasmalogen levels in mammals
  • Method for increasing endogenous plasmalogen levels in mammals
  • Method for increasing endogenous plasmalogen levels in mammals

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] a. Preparation of Alkoxyglycerol Fractions from Shark Liver Oil Alkylglycerols

[0064] An alkoxylglycerol fraction was prepared by saponification of squalene-free shark liver oil according to the following method. Alkoxyglycerols were obtained by saponification of 100 g of desqualenised shark liver oil with 1000 ml of potassium hydroxide (1 M) ethanol solution. The resulting solution containing alkoxyglycerols was extracted with diethyl ether (3 x 300 ml), followed by a distillation step. The resulting white waxy residue contains about 90% alkoxyglycerols.

[0065] b. Incubation of astrocytes with alkoxyglycerols

[0066] Astrocytes were chosen as an in vitro model because this glial cell type is a major component of brain lipid metabolism. Briefly, saponified shark liver oil (100 [mu]M) was added to astrocytes for 24 hours. Following this treatment period, cells were disrupted with methanol and directly derivatized prior to analysis. Cells not supplemented wi...

Embodiment 2

[0073] a. animal research

[0074] Treatment with a control diet, a diet rich in alkylglycerols (equivalent to a daily consumption of 300 mg of alkylglycerols, 340 μmol / day), or a diet rich in alkoxyglycerols (equivalent to a daily consumption of 116 mg of alkoxyglycerols, 340 μmol / day) Adult male Sprague Dawley rats (4 weeks old, Center d'élevage Janvier, Le Genest Saint Isle, France) were fed diet for 3 weeks (n=6 per group). All three diets were similar in composition: 23% saturated fatty acids, 60% monounsaturated fatty acids, 13% linolenic acid, 1.3% alpha-linolenic acid, 1.8% docosahexaenoic acid.

[0075] b. result

[0076] Plasmalogen levels, measured as total DMA, were found to be significantly higher in animals receiving a diet supplemented with alkylglycerols. Supplementation of the diet with the diet supplemented with alkoxyglycerols also resulted in an increase in plasmalogen levels.

[0077] Table 2

[0078] Plasmalogen levels as measured by DMA in erythr...

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Abstract

The present invention relates generally to compounds such as alkylglycerol and alkoxyglycerol for use in increasing the endogenous level of plasmalogens in a mammal. In particular, these compounds are used for increasing the endogenous plasmalogen level to a level greater than the level in healthy mammals. According to the present invention such compounds are also for use in the prevention or treatment of diseases caused or affected by a decreased endogenous level of plasmalogens. A method for the manufacture of a dietary precursor for the use of the present invention is also part of the present disclosure.

Description

field of invention [0001] In general, the present invention relates to compounds, such as alkylglycerols and alkoxyglycerols, for increasing the level of endogenous plasmalogens in mammals. In particular these compounds are useful for increasing endogenous plasmalogen levels above levels in healthy mammals. According to the invention, said compounds are also useful in the prevention or treatment of diseases caused or affected by reduced endogenous plasmalogen levels. Methods of preparing dietary precursors for use in the present invention are also part of this disclosure. Background technique [0002] Plasmalogens, their structures and applications are well known to those skilled in the art. [0003] [0004] Plasmalogens are glyceryl ether phospholipids in which the glycerol moiety is bonded to a 1-alkenyl ether group or a 1-alkyl ether group. Three major classes of plasmalogens have been identified and referred to as choline, ethanolamine, and serine plasmalogens. T...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/08A61K31/23A61K31/231A61K45/06A61P43/00A61P35/00A61P25/28A61P3/02
CPCA61K31/231A23L1/30A23K1/1846C11C3/00A61K45/06A23L1/3006A23K1/1646A61K31/08A61K31/23A23K20/10A23K50/40A23L33/10A23L33/115A61P25/28A61P3/00A61P3/02A61P35/00A61P43/00
Inventor F·德塔亚J-B·贝泽尔盖斯F·迪欧尼斯C·克鲁兹-赫尔南德斯I·马斯雷-埃尔梅莱吉
Owner NESTEC SA
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