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Application of radiolabeled irradiation anthranone or naphtho dianthrone compounds to preparation of antitubercular medicine

A radiopharmaceutical and labeling technology, applied in the direction of radioactive carriers, can solve the problems of no tuberculosis treatment research and reports, and achieve the effect of treating or inhibiting tuberculosis

Inactive Publication Date: 2014-07-09
JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

There are no studies and reports on the radioactive isotope-labeled products of the above compounds as tuberculosis treatment

Method used

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  • Application of radiolabeled irradiation anthranone or naphtho dianthrone compounds to preparation of antitubercular medicine
  • Application of radiolabeled irradiation anthranone or naphtho dianthrone compounds to preparation of antitubercular medicine
  • Application of radiolabeled irradiation anthranone or naphtho dianthrone compounds to preparation of antitubercular medicine

Examples

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Embodiment 1

[0023] Reagent material

[0024] SD rats were purchased from Shanghai Slack Experimental Animal Co., Ltd.; Hezhechongzi was purchased from Beijing Xiantong Times Pharmaceutical Technology Development Co., Ltd.; 131-iodine was purchased from Atom Hi-Tech Co., Ltd.

[0025] method

[0026] The preparation method of 131-iodine-labeled drug:

[0027] Accurately weigh hypericin, protohypericin, pseudohypericin, trumpetin, hydroxyanthraquinone, nude pigment B, nude pigment D, heteronuclein D, and ocher violet, and dissolve them in DMSO , add Iodogin and [131NaI], and incubate at room temperature for 30min. Using thin-layer paper chromatography (TLC), Xinhua No. 1 (1cm×20cm) chromatography paper was used as a support, and samples were spotted with a capillary tube at a distance of 1cm from the lower edge. After natural drying, 0.1M hydrochloric acid was used as a developing agent. After spreading upward for 10 cm in the chromatography cylinder, stop, dry in the air, and measure ...

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Abstract

The invention relates to a radiolabeled irradiation anthranone or naphtho dianthrone compound, which has the specific affinity capability in biosome necrotic tissues and simultaneously comprises chemical elements or isotopes with unstable nucleus. Radiation can be emitted out in a period when the compound is decayed to the stable state, and the radiation is sufficient to damage the adjacent tubercle bacillus for target radiation treatment, so the antitubercular treatment possibility is improved. The compound has a special advantage that the drug resistance tuberculosis can be treated through single-time or multi-time dosage of the radiolabeled irradiation anthranone or naphtha dianthrone compound.

Description

technical field [0001] The present invention relates to radioisotopically labeled solar anthrone or naphthodianthrone compounds comprising chemical elements or isotopes with unstable nuclei which, during their decay to a stable state, emit radiation sufficient to destroy Adjacent tuberculosis bacilli are used in tuberculosis-targeted radiation therapy to produce a cure for tuberculosis. Background of the invention [0002] Tuberculosis is an infection caused by the invasion of Mycobacterium tuberculosis into the body. It is a chronic and slow-onset infectious disease that is prone to occur in young people. Adolescents aged 15 to 35 are the peak age for tuberculosis. The incubation period is 4 to 8 weeks. 80% of them occur in the lungs, and other parts (cervical lymph, meninges, peritoneum, intestines, skin, bones) can also be secondary infections. It is mainly transmitted through the respiratory tract, and the source of infection is tuberculosis patients who have been exp...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K51/04A61K101/02A61K103/00A61K103/10A61K103/32
Inventor 倪以成张健孙自平江岩声陈峰马琳·米兰达
Owner JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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