Application of chickpea sprout extracts in medicines for preventing deficiency of estrogen
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A technology of chickpea sprouts and extracts, which is applied in the direction of drug combinations, medical preparations containing active ingredients, and pharmaceutical formulas, and can solve problems such as the absence of isoflavone extracts from chickpea sprouts
Inactive Publication Date: 2012-06-13
XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
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[0011] So far, there have been no reports at home and abroad about the estrogen-like activity of chickpea sprout isoflavone extract and its...
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Embodiment 1
[0032] Example 1 (Use of Chickpea Sprout Isoflavone Extract in the Preparation of Medicines for Prevention and Treatment of Women's Estrogen Deficiency Menopausal Syndrome)
[0033] Effects of chickpea sprout isoflavone extract on the uterus and estrogen levels of female SD rats:
[0034] Tested drug: Estradiol Valerate, produced by Schering (Guangzhou) Pharmaceutical Co., Ltd., batch number (J20080036), made suspension with corn oil. The chickpea isoflavone extract is completed by our laboratory through the following steps:
[0035] a, the chickpeas are germinated and dried by a conventional method, ground into powder, and passed through a 25-mesh sieve;
[0036] b. Add 2-10 times volume concentration of 10-100% methanol or ethanol or isopropanol or butanol to the dry chickpea bean sprouts, extract 1-15 times with ultrasonic wave or cold soaking or heating and refluxing, each time After 1-3 hours, filter, combine the filtrates, concentrate under reduced pressure until there...
experiment example 2
[0065] Experimental example 2 (the use of chickpea bean sprouts isoflavone extract in the medicine for preventing and treating osteoporosis with estrogen deficiency)
[0066] Osteoprotective effect of chickpea sprout isoflavone extract on ovariectomized SD rats:
[0067] Test drug: Estradiol Valerate, produced by Schering (Guangzhou) Pharmaceutical Co., Ltd., batch number (J20080036), made suspension with corn oil, chickpea isoflavone extract and Example 1 The same, wherein the isoflavone content is 73.36%, calculated and used according to the amount of natural phytoestrogens contained therein, respectively made into solutions with different concentrations, all the drugs are prepared from corn oil, and stored at 4°C for later use.
[0068] Test animals: 10-week-old female SD rats, purchased from the Experimental Animal Center of Xinjiang Institute of Endemic Disease Control (certificate number: 20110222), weighing 220 (±10g). Divided into sham operation group, model group, es...
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Abstract
The invention relates to application of chickpea sprout extracts in medicines for preventing deficiency of estrogen. The chickpea sprout extracts are chickpea sprout isoflavone extracts, are used as estrogen receptor regulator, and are used for preparing medicines and health care products which are used for preventing or treating climacteric syndrome and osteoporosis. Tests show that the chickpea sprout isoflavone extracts can directly act onto the uterus of a patient, can remarkably increase estradiol level in blood serum, have regulating and controlling effects to a hypothalamus-hypophysis- neuroendocrine system, remarkably increase thighbone density and relative bone volume of an SD (Sprague Dawley) rat without the ovary, increase the thickness of bone trabecula, reduce separating degree of the bone trabecula, decrease the quantity of osteoclast, can alleviate bone loss of the thighbone of the rat due to the fact that the ovary of the rat is removed, increase bearing capacity of the thighbone, play an important role in regulating internal secretion conditions of middle-aged and elderly women after menopause, improving menopause symptoms such as hot flash, palpitate, skin dryness and the like and reducing possibility of osteoporosis, and lay a foundation in industrial development of functional factors of chickpeas.
Description
Technical field: [0001] The present invention relates to the use of a chickpea sprout extract as a medicine for preventing and treating estrogen deficiency, in particular to a medicine for preventing and treating menopausal syndrome and osteoporosis caused by a chickpea sprout isoflavone extract the use of. Background technique: [0002] Menopausal syndrome is a symptom of middle-aged and elderly women due to the gradual decline of ovarian function and estrogen level, including hot flashes, palpitations, dry skin, frequent urination, backache and other symptoms, which are closely related to the sudden drop of estrogen level relevant. Osteoporosis is another common disease caused by the decline of estrogen levels in middle-aged and elderly women. The main reason is that the decrease of estrogen levels leads to the weakening of the stimulatory effect of estrogen receptors in bone tissue, which leads to active bone metabolism and insufficiency. In balance, the activity of ost...
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IPC IPC(8): A61K36/48A61P5/30A61P15/12A61P19/10
Inventor 马海蓉阿吉艾克拜尔・艾萨王洁阿布力米提・伊力陈花高彦华
Owner XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
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