Application for changing foreign organs into organs formed by cells of organ receivers

Abstract

Application for changing foreign organs into organs formed by cells of organ receivers includes preparing an animal (an organ provider) with an organ with the size identical to that of an organ of a human body (an organ receiver) at first, and then injecting antibody crosslinking substances of corresponding animal tissue stem cells to the organ of the animal or circulated blood of the animal or the organ receiver before or after organ transplantation. After transplantation surgery is successful, immunosuppressant is used according to conventional dose, and simultaneously, stem cell mobilization agent is injected. The application for changing foreign organs into organs formed by cells of organ receivers has the advantages that organ sources are sufficient, cost is low, and patients can buy suitable organs at any time without waiting for suitable organ donors, and do not need to take immunosuppressive drug during lifetime.

Description

technical field [0001] The invention relates to the field of organ transplantation, in particular to the replacement of allogeneic organs with organs composed of organ recipient cells. Background technique [0002] Diabetes, uremia, aging and other diseases due to degeneration or damage of organ or tissue function can save the life of the patient by transplanting the corresponding organ (or tissue). However, due to the severe shortage of organ sources and immune rejection ( With the exception of identical twins), a large number of precious lives are lost globally each year. [0003] Transplanting animal organs (or tissues) into humans can solve the problem of insufficient organ sources. A more ideal animal is a pig. However, to transplant pig organs to humans, the pig genome must first be modified so that the human immune system will not produce hyperacute rejection of the vascular endothelial cells of pig organs, that is, the pig (organ provider) genome will The gene "kn...

AI Technical Summary

Problems solved by technology

[0005] However, the success of animal experiments does not mean that this achievement can be applied to humans, because there are still several difficulties: (1) Transplanting the organs of ordinary animals into humans cannot pass the barrier of hyperacute rejection of immunity ; (2) If the organs of pigs with weak antigens are used, they will eventually fail due to long-term chronic rejection. Now the heart transplanted from such pigs to monkeys can only survive for one year; (3) even if patients use allogeneic Organs, due to the extreme shortage of organ sources, very few patients waiting in line in the hospital can finally get what they want, and they need to wait for the appearance of organ donors, which will waste a lot of precious time, and many patients died while waiting