Medicine-carrying membrane-covered stent and preparation method thereof

A covered stent and drug-loaded technology, applied in stents, medical science, surgery, etc., can solve problems such as poor control of the process, biliary stricture, obstruction, etc., and achieve the effect of solving benign and malignant biliary strictures

Inactive Publication Date: 2012-07-04
SHANGHAI NAT ENG RES CENT FORNANOTECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this degradable biliary stent involves too many materials, and its process is not easy to control, and the mechanical properties of the degradable stent material are difficult to achieve the strength and elasticity of the existing metal stent
At present, some people hav

Method used

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  • Medicine-carrying membrane-covered stent and preparation method thereof
  • Medicine-carrying membrane-covered stent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] (1) Weigh 0.8g of polycaprolactone, dissolve it in 10mL mixed solution of dimethylformamide and dichloromethane with a volume ratio of 2:8, and prepare an 8% polycaprolactone solution; prepare silk The fibroin aqueous solution is the same as the patent "Preparation of Insoluble Silk Fibroin Film and Silk Fibroin Tube" (Patent No. 03131142.3), that is, the white factory silk is degummed, dissolved, dialyzed, and filtered to obtain an initial concentration of 3% (w / w). Silk fibroin aqueous solution, weigh 0.12g of epirubicin and dissolve it in 200mL of silk fibroin aqueous solution, heat the solution to 50°C in a magnetic stirrer in a water bath and concentrate to obtain a concentration of 2% epirubicin of 30 % silk fibroin aqueous solution;

[0021] (2) Put the bare stent on a metal rod of corresponding diameter. The metal rod is grounded and used as the receiving device of the electrospinning device. The rotating speed of the receiving device is 20rpm, the receiving dis...

Embodiment 2

[0024] (1) Weigh 0.5g of polylactic acid and dissolve it in 10mL of dichloromethane to prepare a 5% polylactic acid solution; weigh 0.7g of chitosan and dissolve it in 10mL of 90% acetic acid solution to prepare a mass Fraction is about 7% chitosan solution, then weigh 0.035g doxorubicin and be dissolved in chitosan solution, obtain the chitosan acetic acid solution that doxorubicin content is 5%;

[0025] (2) Put the bare support on the metal rod of the corresponding diameter. The metal rod is grounded and used as the receiving device of the electrospinning device. The rotating speed of the receiving device is 20rpm, the receiving distance is 8cm, and the polylactic acid is used as the spinning solution. The voltage was 12kV, the flow rate of the solution was 0.1 mL / min, and the spinning was stopped after 1 hour to obtain a scaffold coated with polylactic acid fibers. After the scaffold was removed and vacuum-dried at room temperature for 24 hours to remove the organic solvent...

Embodiment 3

[0029](1) Weigh 0.8g of polycaprolactone, dissolve it in 10mL mixed solution of dimethylformamide and dichloromethane with a volume ratio of 2:8, and prepare an 8% polycaprolactone solution; weigh 0.7g chitosan, is dissolved in the 90% acetic acid solution of 10mL, prepares the chitosan solution that massfraction is about 7%, obtains chitosan acetic acid solution;

[0030] (2) Put the bare stent on a metal rod of corresponding diameter. The metal rod is grounded and used as the receiving device of the electrospinning device. The rotating speed of the receiving device is 10 rpm, the receiving distance is 8 cm, and the polycaprolactone solution is the spinning solution. Adjust the spinning voltage to 10kV, the solution flow rate to 0.1 mL / min, and stop spinning after 1 hour to obtain a scaffold coated with polycaprolactone fibers. Remove the scaffold and remove the organic solvent after vacuum drying at room temperature for 24 hours, and then add I125 particles Spray on the surf...

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Abstract

The invention relates to a medicine-carrying membrane-covered stent and a preparation method thereof. The medicine-carrying membrane-covered stent is covered with a medicine-carrying low-speed degrading fiber layer with an electrostatic spinning method, and the surface of the medicine-carrying low-speed degrading fiber layer is covered with a medicine-carrying low-speed degrading fiber layer with the electrostatic spinning method. The medicine-carrying membrane-covered stent provided by the invention can be used for treating the malignant stricture of a biliary tract, has the action of mechanical expansion and also has the action of topical therapy. The provided medicine-carrying membrane-covered stent is characterized in that medicine can be slowly released to lesion positions so as to perform the therapy effect. Compared with the common bare stent or the common membrane-covered stent, the medicine-carrying membrane-covered stent is characterized by better solving the problem of the benign and malignant stricture of the biliary tract. In addition, the method also can be used for modifying an esophagus stent, a trachea stent and a cardiovascular stent.

Description

technical field [0001] The invention relates to a drug-loaded covered stent and a preparation method thereof, belonging to the field of biomedical materials. Background technique [0002] Due to the development of endoscopic and interventional techniques, and the gradual standardization of ERCP (retrograde cholangiopancreatography) and PTCD (percutaneous transhepatic biliary drainage) techniques, biliary stents have been widely used in cholangioplasty. The efficacy of biliary stent implantation and the quality of life of patients are significantly better than those of simple biliary drainage. Bare metal stents are commonly used clinically at present, and restenosis after stent implantation has always been an insurmountable clinical problem. In order to solve the problem of restenosis after biliary stenting, it has been reported that a layer of polyurethane is covered on the outer layer of the metal stent, which can prevent the tumor from growing inward through the mesh of t...

Claims

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Application Information

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IPC IPC(8): A61F2/82A61L31/16A61L31/10
Inventor 周涓刘训伟孙钢金彩虹何丹农
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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