Paster for treating dental ulcer and preparation method thereof

A technology for oral ulcers and patches, which is applied in the field of composition preparation and can solve the problems of inconvenient transportation and use, short residence time, affecting treatment effects and the like

Inactive Publication Date: 2012-07-25
沈阳长秀医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The dosage form of the medicine for the treatment of oral ulcer at present mainly contains mouthwash, powder, film, patch etc., wherein as the mouthwash of liquid preparation, there are many problems such as lower medicine stability, storage, transportation and use inconvenience; As powder The powder for administration cannot be administered quantitatively, and the powder can be diluted by saliva and dispersed to other parts after contacting saliva in the oral cavity, or swallowed with the swallowing action, which greatly affects the therapeutic effect; more importantly, oral Gargles and powders stay in the affected area for a short time, and the drugs cannot be in contact with the ulcer for a long time, which affects the curative effect. However, the oral adhesive film is still insufficient in terms of adhesion, dissolution rate, and drug loading.

Method used

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  • Paster for treating dental ulcer and preparation method thereof

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Embodiment Construction

[0022] L-Glutamine 33g Sodium azulene sulfonate 0.1g lactose 50.9g carbomer 35g Hydroxypropylmethylcellulose 30g Magnesium stearate 1g 1000 pieces

[0023] Preparation:

[0024] Step 1. Pass L-glutamine and sodium azulene sulfonate through a 120-mesh sieve respectively, and set aside; pass lactose, carbomer, hydroxypropyl methylcellulose, and magnesium stearate through a 100-mesh sieve, set aside; Various raw and auxiliary materials are mixed evenly to obtain a mixture;

[0025] Step 2. The mixture obtained in step 1 is directly compressed into powder tablets, using flat punching, with a diameter of 12 mm and a tablet weight of 0.15 g;

[0026] Step 3. One side of the obtained plain sheet is coated with 10% ethyl cellulose ethanol solution as an anti-adhesive layer.

[0027] L-Glutamine 66g Sodium azulene sulfonate 0.2g lactose 17.8g carbomer 35g Hydroxypropylmethylcellulose 30g Magn...

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Abstract

The invention aims to provide a paster for treating dental ulcer and a preparation method thereof. Aiming at the defects of the existing dental ulcer preparation, the oral paster containing L-glutamine and sodium azulenesulfonate has the advantages of simple preparation process, stable drug release, durable action to ulcer position and remarkable curative effect.

Description

technical field [0001] The invention relates to a patch and a preparation method thereof, in particular to a patch containing L-glutamine and sodium azulenesulfonate for treating oral ulcers and a preparation method thereof, belonging to the technical field of composition preparation. Background technique [0002] Oral ulcer, also known as aphthous ulcer, is a common disease. Its etiology is complex, and it is closely related to autoimmune dysfunction, endocrine dysfunction and genetic factors. During the attack, the oral mucosa is necrotic and ulcerated, and the initial stage of the lesion is hyperemia. , redness, edema, local burning sensation, severe spontaneous pain, and due to the stimulation of chewing and speaking, it may be aggravated day by day. [0003] Sodium azulene sulfonate is a chemical substance extracted from the flowers of Compositae plants, which can increase the synthesis of prostaglandin E2 in the mucosa, promote granulation formation and epithelial cell...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/198A61K31/185A61K9/70A61P1/02
Inventor 房丽娜王艳戴凌松
Owner 沈阳长秀医药有限公司
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