High-efficiency CpG preparation, preparation method thereof and application

A preparation and high-efficiency technology, applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, oil/fat/wax non-active ingredients, etc., can solve problems such as poor stability, harsh storage conditions, and decreased drug efficacy, and achieve Reduced usage, low preparation cost, effect of reduced usage
CN102631675AActive Publication Date: 2012-08-15SOUTH CHINA AGRI UNIV
1 Cites 2 Cited by

Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SOUTH CHINA AGRI UNIV
Publication Date
2012-08-15

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses a high-efficiency CpG preparation, a preparation method thereof and application. The CpG preparation consists of components including 80-120ml of PBS (phosphate buffer solution) of CpG ODN (oligodeoxynucleotide) with the concentration of 10-45mug / ml, 160-180ml of white oil, 10-14ml of span-80, 6-10ml of tween-80 and 20-40ml of EMULSIGEN. The preparation is quite favorable for strengthening antigen uptake ability of antigen presenting cells, promotes formation of Th1 type immune response, can reduce the application amount of vaccine, improves the service effect of the vaccine, and is higher in stability and more convenient to be stored.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention belongs to the technical field of veterinary vaccines, and relates to a veterinary vaccine adjuvant and its preparation method and application, in particular to a high-efficiency vaccine adjuvant CpG preparation and its preparation method and application. Background technique

[0002] Many domestic veterinary vaccine manufacturers use aluminum adjuvants or oil adjuvants for vaccine adjuvants, but these adjuvants have certain side effects. Oil emulsions stimulate local granulomas or inflammatory reactions: aluminum adjuvants can cause injection site The local inflammatory reaction will cause granuloma, and some individual animals will cause stress response and lead to individual death. And the induced immune response belongs to Th2 type, which is not enough to completely protect animals against infection. Although it can enhance humoral immunity, the antibody is mainly IgGⅠ, which cannot significantly improve cell-mediated immune response...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More